{"metadata":{"accession":"A0A6J0UDX7","id":"A0A6J0UDX7_9SAUR","source_organism":{"taxId":"103695","scientificName":"Pogona vitticeps","fullName":"Pogona vitticeps (central bearded dragon)"},"name":"tRNA (carboxymethyluridine(34)-5-O)-methyltransferase","description":["Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis"],"length":709,"sequence":"MSEASPTEFRGISRYKIETQGSKELRGCVTLRYIPSFVVNVSNMELDGVEQRNQKLSKAEKKLRQKQMKARHTLWKHEGIECVSYPTKSLVIANGGLGNGVSRCQLLCVVEKCGLVEVLSMPPNKPYSFVKYGMLEDATRAYNSLNGNKIKVEDSLQSVVLYFNFVEQVPWEDMTPPALPPGLSIIEELISPEEERQLLESIDWAEDEALPNTQKSLKHRRVKHFGYEFRYDNNNIDRDRPLPGGLPDICNTFLEKCLNMGYIKDSPDQLTINQYEPGQGIPPHIDTHSAFEDEIISLSLGAEIVMDFKHPDGRTLAVMLPQRSLLVMSGESRYLWTHGITPRKFDIVQASEGQQVGTITADTGNLTLNKRGTRTSFTFRKVRRSPCPCSYPSVCDSQRKDTAPAFPDNEREALELEKKYVHEVYEEIAMHFSNTRHSPWPRVVEFLRTLPCGAVVADVGCGNGKYLGVNKDLYLFGCDRSKTLVDICGEKGFQAFVGDALSVPIRSGSCDACISIAVIHHFATVERRLMTLSEIVRLLRPGGRALIYVWALEQEYNKQKSKYLKGKRAGSEKEGEIICNTATDTGDSGCRDLLHCSENVTQLEGRQYSANQIFPNELPVHTNRTSFDSQDLLVPWHLKDGTKKSTKQAKVHHPSANSSNVQDCPPVFHRYYHVFCEGELEQLCRRLGGITVQESYYDQGNWCVVLEKQ","proteome":"UP001652642","gene":"ALKBH8","go_terms":[{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008757","name":"S-adenosylmethionine-dependent methyltransferase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"9157eaf34b18aa0229af39d14a77d5f9a5d5ea98","counters":{"domain_architectures":450,"entries":23,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":3,"cdd":2,"pfam":3,"profile":1,"panther":1,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":450}}}