{"metadata":{"accession":"A0A6I9X3F4","id":"A0A6I9X3F4_9SAUR","source_organism":{"taxId":"35019","scientificName":"Thamnophis sirtalis","fullName":"Thamnophis sirtalis"},"name":"[histone H3]-lysine(4) N-trimethyltransferase","description":["Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'"],"length":439,"sequence":"MRAAAPSQMEGLEKFQSPGKGRGLRALRRFVIGELLFSCPAFTCVLTVNERGNHCECCFARYHAEGRRAAGRCKVSIYYCNIICQKQDWPLHKLECSAMCIFGQNWNPSETVRLTARILAKQKTHLERTESEKLLSIKDFESHLDKLDNEKKELIQTDISALHHFYSKHMEYPDNEALVVLFGQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTVAEVRAVQEIEAGDEIFTSYIDLLYPTEDRNDRLKDSYFFTCDCRECFTKEKDKDKLEIRKLNEPPSTEAVRDMIRYARNVIEEFRRAKHYKSPGELQEICELSLDKMGSVFAESNVYMLHMMYQAMGVCLYIQDWEGALRYGQKIIKPYSKHYPSYSLNVASMWLKLGRLYMGLENRSAGVKALKKAIAIMEIAHGKDHPYVIEIKKELETH","proteome":"UP000504617","gene":"SMYD2","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016279","name":"protein-lysine N-methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0042054","name":"histone methyltransferase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"cdb0e2dff944ca9f12bf7c5f8bce1b4131c3a44b","counters":{"domain_architectures":6599,"entries":19,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"profile":1,"smart":1,"cdd":1,"ssf":2,"cathgene3d":5,"pfam":2,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":6599}}}