{"metadata":{"accession":"A0A6I8R2S9","id":"A0A6I8R2S9_XENTR","source_organism":{"taxId":"8364","scientificName":"Xenopus tropicalis","fullName":"Xenopus tropicalis (Western clawed frog)"},"name":"Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1","description":["Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate"],"length":870,"sequence":"VPYLLLRPQLVLLLLFALCLLSVFISAYYLYGWKRGLEPSGSEAQSPDCDEPKISPSRLLPMKPLKPVDSSRTDPLVLVFVESLYSQLGQEIVAILESSRFKYRTEIAPGKGDMPTLTDKDRGRFALIVYENILKYVNLDAWNRELLDKYCVEYGVGIIGFFKANENSLLSAQLKGFPLYLHSNLGLKDCSINPKSPLLYITRPNQVDKGDLPGEDWTVFQSNHSTYEPVLLAKTKSAESIPHLSVDAALHTTVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVSFLTGKRLSLPLNRYVLVDIDDIFVGKEGTRMKVEDVKALYDTQMELRTHIPNFTFNLGFSGKFFHTGTDAEDEGDDLLLSYVKQFWWFPHMWSHMQPHLFHNQSVLAEQMALNRKFAVEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKQIWGIKVTSTEEYPHLKPARYRRGFVHNGIMVLPRQTCGLFTHTIFYNEYPGGPVELDKIINGGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFKHLVQFLNTWTNLKLETLPPVQLAHKYFQIFPEEKDPLWQDPCEDKRHKDIWSKEKTCDRFPKLLIIGPQKTGTTALYLFLGMHSDLSSNYPSSETFEEIQFFNGQNYHKGIDWFMEFFPIPSNTTSDFYFEKSANYFDSELAPRRVAALLPKAKIITILINPADRAYSWYQHQRAHDDPVAMKYTFQEVITAGPEAPQRLRALQNRCLVPGWYSTHIERWMNHFHANQILVLDGKLLRTEPANVMETVQKFLGVTNAMDYHKTLAFDPKKGFWCQLLDGGRTKCLGKSKGRKYPDMDSDSRSFLMDYYRDHNIELSKLLYKMGQTLPTWLREELQSTR","proteome":null,"gene":"ndst1","go_terms":[{"identifier":"GO:0015016","name":"heparan sulfate N-sulfotransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016787","name":"hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008146","name":"sulfotransferase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"fd663a2b02674519d42562c3f8e445395cd2acde","counters":{"domain_architectures":4644,"entries":11,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"pfam":3,"cathgene3d":1,"ssf":1,"panther":1,"interpro":5},"proteome":0,"taxonomy":1,"similar_proteins":4644}}}