{"metadata":{"accession":"A0A6I8N0F4","id":"A0A6I8N0F4_ORNAN","source_organism":{"taxId":"9258","scientificName":"Ornithorhynchus anatinus","fullName":"Ornithorhynchus anatinus (Duckbill platypus)"},"name":"Ribosomal RNA-processing protein 8","description":["Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown"],"length":429,"sequence":"MFAEPPWAHEARGLRDVVVPAPTHPPSSKPQKGRGQQKLLAVLQKLEAAALPRQLAPAWPCGSEGGDSDDSSGEEARGRKKKLKKRRSNPEAEAPDLHAKASPPPGTGKKRRRKQGAPAPVDEAPTPSLPAPGATGGQEPKEGEAGLQTPDRPLSRKQWRNRQKNKRRNKNKFQPSGKQPPPTDAASASGPAPETPPAPEEPGAEARSRADALRARMEERLEGARFRCLNEQLYTGPSSAARRLFRDDPDAFQIYHRGFQAQLRHWPLRPVEAIIRNLRRRPASLVVADFGCGDCQLASGIRNPVHCFDLAALDPRVVVCDMAKVPLEDASVDVAVFCLSLMGTNLRDFLEEANRVLKPGGLLKVAEVASRFEDVRAFLGALAQLGFKNISKDLSNSHFYLFDFRKTGPPQAKGRLPGLALRPCVYKRR","proteome":"UP000002279","gene":"RRP8","go_terms":[{"identifier":"GO:0008168","name":"methyltransferase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"8063866de715fd1b946088795e4f3f20d56c5116","counters":{"domain_architectures":4064,"entries":9,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":1,"cdd":1,"panther":1,"pfam":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":4064}}}