{"metadata":{"accession":"A0A663MS25","id":"A0A663MS25_ATHCN","source_organism":{"taxId":"194338","scientificName":"Athene cunicularia","fullName":"Athene cunicularia (Burrowing owl)"},"name":"DNA-directed RNA polymerase subunit","description":["DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway","DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates"],"length":206,"sequence":"MFVLVEMTDTVRIPPWQFQRKLNESIAEELNKKLANKVVYNVGLCICLYDITKLEDSYIFPGDGASHTKVHFRYVVFHPFLDEILIGQIKGCSQDGVHVSIGFFDDIVIPPESLQQPAKFDEAEQVWVWEYETEEGAHDLYMDIGEEIRFRVVDETFVDTSPTGPSSAEASTSNATEEVQKKEAPYTLVGSISEPGLGLLSWWTNS","proteome":"UP000472269","gene":"POLR3H","go_terms":[{"identifier":"GO:0006351","name":"DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003899","name":"DNA-directed RNA polymerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006352","name":"DNA-templated transcription initiation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"fd05722550f5a454a1e6be8aa835c4de81dde895","counters":{"domain_architectures":3909,"entries":15,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cathgene3d":2,"cdd":1,"pfam":2,"ncbifam":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":3909}}}