{"metadata":{"accession":"A0A5E4C607","id":"A0A5E4C607_MARMO","source_organism":{"taxId":"9995","scientificName":"Marmota monax","fullName":"Marmota monax (Woodchuck)"},"name":"DnaJ homolog subfamily C member 2","description":["Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation"],"length":626,"sequence":"MLLLPSAADGQGTAITHALTSASALCQVEPVGRWFEAFVKRRTRNASASFQELEDKKELSEESEDEELQLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYKATQRQIKAAHKAMVLKHHPDKRKAAGEPIKEGDNDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKDNFFEVFSPVFERNSRWSNKKNVPKLGDMNSSFEDVDAFYSFWYNFDSWREFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEIRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELARSRKGCSGKTEEINEQIRKEKEEAEARMRQASKNAEKSTGGGGSSSKNWSEDDLQLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGIKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHGVVPQADNATPSERFEDFTPWTTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMKRYKVVFEFIDSIIICNVVSILVTAVKWELVEMVKAKKAAQEQVLNASRLKK","proteome":"UP000335636","gene":"GHT09_001718","go_terms":[{"identifier":"GO:0030544","name":"Hsp70 protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043022","name":"ribosome binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006450","name":"regulation of translational fidelity","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0051083","name":"'de novo' cotranslational protein folding","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"fb127eeab32ebccd576532cf809bf4e05bbf511d","counters":{"domain_architectures":918,"entries":31,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cdd":3,"ssf":2,"cathgene3d":3,"smart":2,"pfam":4,"profile":4,"panther":1,"prosite":1,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":918}}}