{"metadata":{"accession":"A0A511MHG4","id":"A0A511MHG4_9NOCA","source_organism":{"taxId":"1210091","scientificName":"Nocardia ninae NBRC 108245","fullName":"Nocardia ninae NBRC 108245"},"name":"ADP-dependent (S)-NAD(P)H-hydrate dehydratase","description":["Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration","Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration"],"length":482,"sequence":"MSTQRGYFTADEVRAAEAELFTRVPDGVPMQRAAHGLATVVAGELRVRTGGVAGRSVTLLVGSGDNGGDALWAGSMLRRRGVAVTAVLLNPDRAHAKGLAALRKAGGRVRDEVGAPDLVIDGIVGISGHGALRPDAAELVAALEVPIVAADLPSGVDPDTGAITGPAVRAAVTVAFGAYKPVHVLAAPHCGRIELVPIGLQLPEPKLAAPAPASIGASWPVPDEHDDKYTQGVTGVCAGSADYPGAAVLCTGAAVLATSGMVRYAGTGSADVLAEFPEVIATQHVSEVGRVQAWVFGPGAGTDADARKRLTEILATDLPVVVDADGLTMLAAEPELVRGRSAPTVLTPHAGEFARLTGAEIGADRVAAARALAEDWRLTVLLKGRATVVATPDAPVLVNEAGASWAATAGAGDVLSGIIGALLAAGHTPAWAAASAARAHSLAANLAAHEGHPEAAPISATPLLHHLRPAIRTLRSLARPEL","proteome":"UP000321424","gene":"nnrD","go_terms":[{"identifier":"GO:0016836","name":"hydro-lyase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0052855","name":"ADP-dependent NAD(P)H-hydrate dehydratase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"2d3cc4a65e0d282cab6625d9174661852f47cd75","counters":{"domain_architectures":19697,"entries":20,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"profile":2,"pfam":2,"cdd":1,"pirsf":1,"hamap":1,"panther":1,"ncbifam":1,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":19697}}}