{"metadata":{"accession":"A0A4X2KSI9","id":"A0A4X2KSI9_VOMUR","source_organism":{"taxId":"29139","scientificName":"Vombatus ursinus","fullName":"Vombatus ursinus (Common wombat)"},"name":"Bifunctional apoptosis regulator","description":["Membrane-bound E3 ubiquitin ligase that plays a role in several processes including apoptosis regulation or reticulum endoplasmic stress. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. Contributes to the dynamic control of IRE1/ERN1 signaling during ER stress by inducing BAX inhibitor 1/TMBIM6 proteasomal degradation. Promotes the activation of TGF-beta signaling by mediating the 'Lys-63'-linked ubiquitination of TGFBR1 which is critical to activate the pathway. Together with NGFR, negatively regulates NF-kappa-B and JNK-related signaling pathways. Promotes the proteasome-mediated degradation of PNPLA3, a protein involveld in lipid metabolism"],"length":446,"sequence":"MEDVQLIAPNVRSTEEEPVPGVSRQISVSEFSCHCCYDILVNPTTLNCGHSFCRHCLALWWVSSKKTECPECREKWEGFPKVNILLRDAIEKLFPDAIKLRLEDIQQNSDIVHSLAAFHKYGNDQISVAPNAGRANPQRGGGFFSGVLTALTGVAVVLLVYHWSSRESEHDLLVHKSVAKWTAEEVIFWLEQLGPWASLYRERFLSERVNGRLLLTLTDEDFSKAPYNIENSSHRKAIIMELERVKTLGVKPPQNLWEYKAVNPGKSLFLLYALKSSPRLSMLYLYLFDYAETFLPFIHTICPVQEKEDIITKFFDFKEPTWKQWREFLVKYSFLPYQLIAEFAWDWLDVHYWTSRFLIVNAMLLSVLELFSFWRIWSRNELKTVPHIMWSHFWKVSTQGLFVAIFWPIIPQFICNCLFYWALYFNPIINIDLVVKEVRRLETQVL","proteome":"UP000314987","gene":"BFAR","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c21cbfe4551580ddff6ac5b414dc153025e6bdde","counters":{"domain_architectures":703,"entries":19,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"cdd":2,"pfam":2,"smart":2,"profile":2,"panther":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":703}}}