{"metadata":{"accession":"A0A4W2G315","id":"A0A4W2G315_BOBOX","source_organism":{"taxId":"30522","scientificName":"Bos indicus x Bos taurus","fullName":"Bos indicus x Bos taurus (Hybrid cattle)"},"name":"Guanine nucleotide-binding protein subunit alpha","description":["Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems","Member of the G-protein alpha subunit family that plays a crucial role in intracellular signaling. Functions as a molecular switch, transducing signals from G protein-coupled receptors (GPCRs) to downstream effectors. In collaboration with the adapter protein TTC1, promotes HRAS activation and ERK1/2 phosphorylation independently of phospholipase Cbeta signaling. Also initiates EMR2-mediated signaling, leading to activation of Akt, MAPK, and NF-kappa-B, which in turn drives macrophage differentiation and inflammatory responses"],"length":374,"sequence":"MARSLTWRCCPWCLTEDEKSAARIDQEINKILLEQKKRDRGELKLLLLGPGESGKSTFIKQMRIIHGAGYSEEDRKNFRPLVYQNIFISMRSMIEAMERLQIPFSWPESKHHASVIMSQDPYKVTKFEKRHAVAMQWLWEDTGIRACYERRREFHLLDSAVYYLSNLDRITEEGYIPTAQDVLRSRMPTTGINEYCFSVQKTNLRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQCLEENNQENRMKESLALFGTILELPWFKSTSVILFLNKTDILEEKIPTSHLATYFPSFRGPKQDAEAAKKFILDMYTRMYAGCVDGADGGRKGPRSRRLFSHYTCATDTQNIRKVFKDVRDSVLARYLDEINLL","proteome":"UP000314981","gene":"GNA15","go_terms":[{"identifier":"GO:0003924","name":"GTPase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019001","name":"guanyl nucleotide binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0031683","name":"G-protein beta/gamma-subunit complex binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0001664","name":"G protein-coupled receptor binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"53ae36c3e9ecf4c3a6c7f817a0745ff8d4c5b7bc","counters":{"domain_architectures":36144,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"smart":1,"pfam":1,"ssf":2,"profile":1,"cdd":1,"cathgene3d":2,"panther":1,"prints":2,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":36144}}}