{"metadata":{"accession":"A0A482AU60","id":"WTF23_SCHKA","source_organism":{"taxId":"204045","scientificName":"Schizosaccharomyces kambucha","fullName":"Schizosaccharomyces kambucha (Fission yeast)"},"name":"Meiotic drive suppressor wtf23","description":["Acts as a suppressor component of the dual wtf meiotic drive system, and can suppress but not confer meiotic drive by compatible poisons (PubMed:32032353). Wtf meiotic drive systems promote unequal transmission of alleles from the parental zygote to progeny spores by encoding a poison and an antidote from the same locus; the poison is trans-acting and forms toxic aggregates in all spores within an ascus, wherease the antidote is spore-specific and targets aggregates for degradation by the vacuole (By similarity). Meiotic drive by wtf systems therefore lead to poisoning of all progeny that do not inherit the dual poison/antidote allele, or express a compatible antidote (By similarity)"],"length":336,"sequence":"MKNNYTSLKSPIDEEDELKTGHEIDLEKGLLPEYDSEEEGALPPYSDHARVSNPPNTHRENHSSGTTDDSSPFLIKLLISFTPIVLLNALAVWYLKYKDAFFKNYGAAEWTLFGFWCLVCTLVLIILTYFYETWTKAVKVTVIFLAQCIKVTAVFLAQCVKGLFNIRREMMIIIWILWLIICCILFGCVKDGRLNFNKALICSTCTISAVLFLIVSSVCIPIWTLWRALSGMLQVLGIHGIIAVLVNGSMSLFGKHFGWRGYEIEGFVLFFTSNALFLYEMERPGVLKRMRNTTGNVIGYICGGIEDAFRRIKNAFRGANDNNNIPLGEMDVEGEV","proteome":null,"gene":"wtf23","go_terms":[{"identifier":"GO:0110134","name":"meiotic drive","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"9248a17bf28971939a5b1525f1771aee2dd0b6be","counters":{"domain_architectures":113,"entries":2,"isoforms":0,"proteomes":0,"sets":0,"structures":0,"taxa":1,"dbEntries":{"pfam":1,"interpro":1},"proteome":0,"taxonomy":1,"similar_proteins":113}}}