{"metadata":{"accession":"A0A437APK5","id":"A0A437APK5_9MICR","source_organism":{"taxId":"291195","scientificName":"Tubulinosema ratisbonensis","fullName":"Tubulinosema ratisbonensis"},"name":"DNA 3'-5' helicase","description":["ATP-dependent 3'-5' DNA helicase/translocase; binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex. When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/SSL2, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/SSL2 is required for promoter opening and promoter escape"],"length":672,"sequence":"MSDTLIPKKARQHTFTKENLILKPDHSSKPLFTNYDSTIILETFSRNAKXATDFLIAIAEPITRPASIHEYRITPYSLYAAVSVGLTTEDILQTLDSFSKNYLPKGLTSFIKECTLSYGKVRLLIKGGNFYIESEKESIIKHLKNDSVIKKCLKLVSNENIPENSEEEEILNKIELQNEKIELIKKRCIELXYPLLEEYDFKNDTSKNLKIDLKDSVQIRTYQEVSLNKMFGNSRARSGIIVLPCGSGKTLVGITAICTIKKPTIIFCSSAVSVEQWKQQILMFTNMKDNVCRFTSDKKEMFNEEGILITTYTMLAFSGKRSHEAKKVMDWLSNKEWGLMVLDEVHVVPAMMFRKVISLINHKCKLGLTATLVREDDKIEDLNFLIGPKLYEADWQDLSAKGHIANVECVEIICEMTAEFYREYLRQPKRRRVLSIMNPXKFQICDFLIKKHESLGEKIIVFSDNVLALKTYALKLNKPFIYGPTSQTERMTILKQFQNNPKINTIFLSKVGDTSIDLPEASCLIQISSHFGSRRQEAQRLGRVLRAKRRHDPGFXVFFYSLVSSDTEEIYYSTKRQQFLIDQGYSFRTVLSVEGFDKADQKIFSTKSEQKELLTSVLLVSEQDLLSEESDDFDRIESSKKKASSHSGGEGMAYVEKNKERHILFRKQDKKK","proteome":"UP000282876","gene":"TUBRATIS_003600","go_terms":[{"identifier":"GO:0003678","name":"DNA helicase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006289","name":"nucleotide-excision repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006367","name":"transcription initiation at RNA polymerase II promoter","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016787","name":"hydrolase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"487df75ccf86f62b8c93874bb22f9740938e72c3","counters":{"domain_architectures":9006,"entries":22,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"pfam":3,"ssf":1,"cathgene3d":1,"cdd":2,"smart":2,"profile":2,"panther":1,"ncbifam":1,"prints":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":9006}}}