{"metadata":{"accession":"A0A3P9P7S4","id":"A0A3P9P7S4_POERE","source_organism":{"taxId":"8081","scientificName":"Poecilia reticulata","fullName":"Poecilia reticulata (Guppy)"},"name":"Phosphoinositide phospholipase C","description":["The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain"],"length":1858,"sequence":"MAELEVCRNLSLERVERCMSVMQSGTQMVKLKAGSKGLVRLFYLDEHRSCIRWKPSRKSEKAKITIDSLYKVTEGGQSDIFHRHADGNFDQACCFTVYHGNHMESLDLVTSNAEEARTWITGLRYLMAGISDEDSLAKRQRTHDQWMKQTFEEADKNGDGLLNIDEIYQLLHKLNVNLPRRKVKQMFQEADTDDHQGTLTYEEFSVFYKMMSLRRDLFLLMMAYSDRKDHLTVEELANFLRNEQKMTNVTSEYVAEIFDKFEVSDENKQRGVLGIEGFTSFMRSPTCDIFNPLHHEVNQDMEQPLCNYFIASSHNTYLTGDQLLSHSKTDMYAWVLQSGCRCVEVDCWDGPDGEPMVQHGYTLTSKITFKSVIETINKYAFINNQYPVILSIENHCSIQQQKKIAEYLREIFADKLDVGEVLSRDSKMLPSPHSLQGKILIKGKRLPAYLSADAEEGEVSDDDSADEIEEDFKLKSSNGNGNHQVESHIRKKLDSLLKESRIVDKEDTDSFSIRALLRATHQGLQKNLRQSSKGVLKKSQSRSLITTLKQKRHSKSRLACQSVEKEEEVQERSGREAGGQFNRGGRKRKTMKLSRDLSNLVVFTNSVASQECLNEGTPGDVLSFSETRAQSLVNHRTEQFLAFNQRQLSRIYPSAYRIDSSNFNPQFYWNVGCQLVALNYQTDGRMMQLNRSKFMVNGGIGYVLKPPPMCKGSFNPFSDDPLPAYPKKQLVLKIISGQQLPKPPDSMLGDRGEIIDPFVEVEIIGLPIDCCKEQTRVVDDNGFNPVWEETLSFTLHMAELALVRFLVWDHDPIGRDFIGQRTVAFSSLMPGYRHVYLEGLTEASIFVHVSVHDVYGKGHQLRGIRGFFNRSSKSSVDTNTSGLRKRSISDHLLRRTASAPAKGRKKTKMALSESVASISDHRNGTDAGASGGEGLSARAEGAEKPLQPRAPLVHRPISMPLDRLLQGQLSICSPDKEQHDVGADTIIGASRFNRPRSSSADAFFEPSFSVKSLVSTPPKTNRKKERDQPEETSYLVIGGGGIRKEEVYVNYQSEQSKSNNFPKEPEKAASMSPLTNSQTTSEKPETSSNSTTFTLAPSSSSSSSSVPSSLPAVSVTSFAPSSLHDSTISRLIDGVSLGIEQDTCCSVSALIDQFECTGDLRNLTTPSQTVTSSHLNFRATSPNFRKDLRSPLINKMASPKIKPLTNSQKSSHVHSNICSPNKNKDKLAAALIWSPETAELEEVYTILDEEVLTPVSVYNLRKQTVHVQADTTGSTPCSSLGSSPVKTIQNLGKGSSGERMWGERQEVVEPEERVYEEVEDAPFAAPKTERATSERYMSSFSSDRVQTLHHSAGESFTEVELNVDEDPSQIMPNQSKQWGRLSSPVKHQAIYQNHNFSRKYPQTLSPTQSSHLASSQFSFPVNKQCRQMTNHHQQNGSQLPLGQSYISSRPLNPGALRQNSYPIPKELNNSQTSDLRSCSSTLLFNESHQQRPENNQIKTERGGFHNGFSSAESFLHQCSASQNRSRQRALCSPSSECKASRSQLDHTCIMPSLESKTSQNIQLHSQGQTQVLQTGKYKTNLIHSRHNQPSKVRDSLQSNSGASLAYLQSSLSVTDSTPRKPCKSKSLGDLTSEDISCNFQSKYNIISRSFITPHITRPKPMDTTGKHSFHTKSNDTLTEQLHRLVSLELDDGLKERPQSTQLQQEAKIQSPQPQEANVTPIVSGDTDDSPPPMLARRLSSRSQSRVRHINSRARERQQEALKARPGVAISNGDSVGGVVWRNKPSLQNQPPNRHSTGSYIAGYLDELEDRGLPEGACTSVRYGNMDHFRDRYYTDDSLPLGITSHYDSEPEVYFLLRL","proteome":"UP000242638","gene":null,"go_terms":[{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008081","name":"phosphoric diester hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006629","name":"lipid metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004435","name":"phosphatidylinositol-4,5-bisphosphate phospholipase C activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035556","name":"intracellular signal transduction","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"72bd174eafcfd47b39c574bf4479c14f0cb5652f","counters":{"domain_architectures":7155,"entries":41,"isoforms":0,"proteomes":1,"sets":6,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"ssf":4,"pfam":5,"smart":5,"profile":5,"cdd":2,"panther":1,"prosite":1,"prints":1,"interpro":13},"proteome":1,"taxonomy":1,"similar_proteins":7155}}}