{"metadata":{"accession":"A0A3B4EX29","id":"A0A3B4EX29_9CICH","source_organism":{"taxId":"303518","scientificName":"Pundamilia nyererei","fullName":"Pundamilia nyererei"},"name":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma","description":["Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis"],"length":1311,"sequence":"MAGTSGFFSNGPVPWMDNATEMNNLYRDLELGTVLTLFYSKKSQRPERRTFQVKLETRTIIWTRGTDKIEGEIDIREIKEIRSGQKSRDFDRYVEDSAARLDQAHCFVILYGTEFRLKSLSLAATSDEEMTMWVQGLTSLVTDTLKSPTPLQIERWLRKQFYAVDRNREDRISCKDLKSMLSQVNYRVPNMRFLREKLPDSEMRNGDVSFSQFAQLYRSLMFDAQKNMEIPFLQRFIDRPEQRISLEDFKSFLLESQKEMWATDNNKVQEFMFGYLKDPLREVEQPYFQQDEFLTYLFSKENTIWDSSLDQVCPENMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPEGMPVIYHGHTLTTKIKFSDVLTTIKEHAFVTSEYPIILSIEDHCSIVQQRNMATHFKKVFGDMLLTKAVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVSTTTPYSENDISNSIKNGILYLEDPINHEWYPHFFVLTSSKIYYSEETSSNPGNDDEEEHREVSYGMDQHVTEKWFHGKLGAGRDGRQIAERLLSEYCLETGAPDGSFLVRESETFVGDYTLSFWRSGRVQHCRIHSRQEAGSPKFYLTDNLVFDTLFALITHYQQVALRCNEFEMKLTEPVPQTNAHESKEWYHANLSRSHAENMLMRVPRDGAFLVRKRAEPNSFAISFRAEGKIKHCRVQQEGQTVVLGTSEFDSLVDLISYYEKHPLYRKMKLRYPINEDTLEKIGTAEPDYGSLYEGRNPGFYVEANQMPTFKCTVRAMYEYKAQRDDELSFTKNAIISNVEKQEGGWWKGDCGGKKQMWFPANYVEEISPSAAEPDRTEITENSPLGDMLRGSLDVSACQINIRTEGKGSRPYVFTLTQNTPVRIGIPLDIAANTQEELKEWVFKIREVTLTSEAKIEEGKMMERRKKIALELSDLVIYCRPVPFDEEKIGTERACFRDMSSFPETKAEKYVNKIKGKKFLQYNRLQLSRIYPRGQRLDSSNYDPLPMWLCGSQLVALNFQTGDKPMQMNQALFMLNGRSGYVLQPPIMRDDNFDPFDRQTLRGVEQVSLEIEVLGSRHLPKHGRGIVCPLIEIEVCGAEYDSAKQKTDSEADNGLNPTWPRKTFQFTVCNSAFAFLRFVVYEIDMFNDQNFLAQATFPIHGLKTGYRSVPLTNSYNEDLELASLLVHMDITRGRDENGEVLSPFAAVGTSSVSATAQSVRERFGELSSVSSTSSSMSPLPQSPAQAMAYRGREGSFESRYQSPIDDFRVSQETLLDMDAQNRRIPRRTRVENRV","proteome":"UP000695023","gene":"plcg1","go_terms":[{"identifier":"GO:0008081","name":"phosphoric diester hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006629","name":"lipid metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004435","name":"phosphatidylinositol-4,5-bisphosphate phospholipase C activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035556","name":"intracellular signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0009395","name":"phospholipid catabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"e586705e4b26c278515616ba16ad71775b8d337f","counters":{"domain_architectures":1326,"entries":63,"isoforms":0,"proteomes":1,"sets":10,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":6,"ssf":6,"profile":6,"cdd":6,"smart":6,"pfam":7,"pirsf":1,"panther":1,"prints":3,"prosite":1,"interpro":20},"proteome":1,"taxonomy":1,"similar_proteins":1326}}}