{"metadata":{"accession":"A0A3B3CZY2","id":"A0A3B3CZY2_ORYME","source_organism":{"taxId":"30732","scientificName":"Oryzias melastigma","fullName":"Oryzias melastigma (Marine medaka)"},"name":"Sodium channel protein","description":["Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient","Pore-forming subunit of a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues"],"length":2024,"sequence":"MAQLLVPPGPDSFRPFVPESLAAIERRIAEEEAKRPRAERRSDSDDENGPKPNSDLEAGKSLPFIYGDTPSHLVSTPLEDIDPFYSNQKTFIVLNRGKAIFRFNATSALYILTPFNPLRRIAIRVLVHSMFSMLIMFTILTNCAFMTLSSPPDWAKNVEYTFTGIYTFESLIKILARGFCVGKFTFLRDPWNWLDFSVILMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRQKCVRMYTPGNATNSSLIANDTMYYNGSLSGFNLSFVENATESTFNWTEYISDESNYYYLPGRRDALLCGNGSGAGLCPEGFVCIKAGRNPDYGYTSFDTFSWAFLSLFRLMTQDYWENLYQQTLRAAGKPYMIFFVLVIFLGSFYLVNLILAVVAMAYDEQNQATIEEAQQKEEEFQAMLEQLKRQQEEAQVAAAAATESGEYSGRGDPTSESSSGTSKLSSKSAKERRNRRKKRKQREEEEEREGRDKFHKSESEDSIKRSTFRFSIDANRLSYEKRCSSPNQSLLSVRGSIFSPRRNSRASLFSFRGRARDMGSENDFADDEHSTFEEADSRRGSLFLPRRTERRCSVVSQTSLGAPRIMLPANGKMHCTVDCNGVVSLVGGTSVTTSPVGLLQPEGTTTDTELKKRRSGFHQPSMDYLDEPGPRQRAMSMGSILTNTMEELEESRQKCPPCWYRFANMCLIWDCCPAWLKIKEVVSTVVMDPFVDLTITICIVLNTLFMAMEHYPMTKEFDNVLSVGNLVFTGIFTAEMCLKIIALDPYYYFQQGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYKECKCKISQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDEDSEMNNLQIAVGRIQRGFAFVKKKVRQLLRSLCFCGAGKGSGLVEESKPLDELHSNGKGNCISNHTSLEITKDGTGVYMMEGNGRPGGGLVVGVVGGDTTGKYPVEESDYMSFIHNPSLTVTVPIAVGESDFENLNTEDFSSDSSDVEGSKEKIDVEPQPLSSSEGSTVDIRPPGDGVDSVELEPEESLDPEACFTEGCVSRFQCCQVDEEGNHFKSWWTLRKTCFIIVEHNWFESFIIFMILLSSGALAFEDVYIEQRRTIKTVLEYADKVFTYVFILEMLLKWVAYGFVKYFTNAWCWLDFLIVDVSLVSLVANALGYSELSAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYYHCINTTTEEMFPIEVVNNKTECLLLVNDSARWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDLEDQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANAFQGCVFDCITKQAFDIVIMILICLNMVTMMVETDDQTKEMDNILYWINLVFIVLFTGECVLKIISLRHYYFTIGWNIFDFVVVILSIVGMFLSEVIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKESGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNKREPDCDSQLEHPGNNYKGNCGNPSVGIFFFVSYIIICFLIVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWERFDPDATQFVEYCKLSDFADALDPPLRIPKPNMIQLVQMDLPMVSGERIHCLDILFAFTKRVLGEGGEMDVLRGQMEERFMASNPSKVSYEPITTTLRRKQEEMSAIIIQRAFRRYLIRQAMKKASAMYKEKLKDGIRDPDKDVMVISKFNENSTSDKTDMTPSTASPPSYNSVTKSDKDKYEKENREKENKGKDFKDRKK","proteome":"UP000261560","gene":null,"go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005261","name":"monoatomic cation channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005886","name":"plasma membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005216","name":"monoatomic ion channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006811","name":"monoatomic ion transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0055085","name":"transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005248","name":"voltage-gated sodium channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006814","name":"sodium ion transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0001518","name":"voltage-gated sodium channel complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"7b94df7e25d387cf7a66a76a97a44bf62628ebd2","counters":{"domain_architectures":9002,"entries":24,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"ssf":1,"cdd":2,"pfam":4,"smart":1,"profile":1,"panther":1,"prints":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":9002}}}