{"metadata":{"accession":"A0A3B1IGN6","id":"A0A3B1IGN6_ASTMX","source_organism":{"taxId":"7994","scientificName":"Astyanax mexicanus","fullName":"Astyanax mexicanus (Blind cave fish)"},"name":"GDP-fucose protein O-fucosyltransferase 2","description":["Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm"],"length":449,"sequence":"MRVLRVMADVRGSGLCGLCYYYYGIVLLCFYSALFSCTLSSEQDAFRAGNPTGAPVAAAARDIRYLLYDVNPPEGFNLRRDVYIRMASLVKTLRKQGDWVLVLPPWGRLYHWKSSDVHQLRIPWAEFFSLNSLQANVPVIEYEEFIAESGGPFIDQVLVLQNYAEGWTEGKWEEKVDERPCIERLMYTKDKQGYYRGWFWGYEETRALNVSCISAQGHASILAPFLQENITAISVLLDRAETVLHDHYAGKDYWDTRRSMVFAKHLRMIGDQFRAKYLNSTDEQDHTPYSEDWTRMKAKLGSAKGGPYLGVHLRRSDFIWGHRDDVPSLKGAVKKIRSLMKKNKLDKVFIATDADEEEVAKLRKRLPEMIRYEPSPEDLELLKDGGVAIIDQWICAHARFFIGTSVSTFSFRIHEEREIMGFDPKTTYNRFCGDLEKECEQPTHWKIVY","proteome":"UP000018467","gene":null,"go_terms":[{"identifier":"GO:0046922","name":"peptide-O-fucosyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0036066","name":"protein O-linked glycosylation via fucose","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ed7b567cc863f572716fedf1cc7b81fac229d2a1","counters":{"domain_architectures":28158,"entries":7,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"cdd":1,"panther":1,"pfam":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":28158}}}