{"metadata":{"accession":"A0A384AI61","id":"A0A384AI61_BALAC","source_organism":{"taxId":"9767","scientificName":"Balaenoptera acutorostrata","fullName":"Balaenoptera acutorostrata (Common minke whale)"},"name":"DAZ-associated protein 2","description":["In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1. In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters. This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death. Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes. Plays a role in stress granule formation"],"length":86,"sequence":"MNGRGQYPPQPAYPAQPPGNPVCPQTLHLPQVPPCTDASPACSEVCPTGYPPSTAQLAVMQGAHVLVTQWKRNFSVGGSDGDYTIR","proteome":"UP001652580","gene":"LOC103000206","go_terms":null,"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"1c6c9e1140f1ba396a396ba6f8295378c7aaad0f","counters":{"domain_architectures":1542,"entries":3,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"pfam":1,"panther":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":1542}}}