{"metadata":{"accession":"A0A370C5G7","id":"A0A370C5G7_ASPNG","source_organism":{"taxId":"1353008","scientificName":"Aspergillus niger ATCC 13496","fullName":"Aspergillus niger ATCC 13496"},"name":"4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase","description":["Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme"],"length":342,"sequence":"MSTDKITFLTNWHATPYHAPLYLAQSKGYFKEEGLKVALLEPNDPSDVTEIIGSGKVDMGFKAMIHTLAAKARNFPVTSIGSLLDEPFTGVVYLKDSGITEDFRSLKGKKIGYVGEFGKIQIDELTKYYGMTADDYTAVRCGMNVTKAIIRGDIDAGIGLENVQMVELAEWLATQGRPRDDVQMLRIDQLAELGCCCFCSILYIANDAFLAANPEKVQKFMRAVKRATDYVLAEPARAFEEYVDMKPIMGTPVNRKIFERSFAYFSRDLKNVSRDWAKVTNYGKRLGILSADFVANYTNDYLSWGLDADSTDPLGDQKRMAELQKKVAAEGGYKRLEVASSA","proteome":null,"gene":"M747DRAFT_293533","go_terms":[{"identifier":"GO:0009228","name":"thiamine biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a7843b174854e51b1f7bf70c154a1e948dc81e7c","counters":{"domain_architectures":65119,"entries":7,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cdd":1,"cathgene3d":1,"panther":1,"pfam":1,"interpro":2},"proteome":0,"taxonomy":1,"similar_proteins":65119}}}