{"metadata":{"accession":"A0A340WCD3","id":"A0A340WCD3_LIPVE","source_organism":{"taxId":"118797","scientificName":"Lipotes vexillifer","fullName":"Lipotes vexillifer (Yangtze river dolphin)"},"name":"Receptor-type tyrosine-protein phosphatase C","description":["Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity"],"length":1121,"sequence":"MTMYLWLKLLAFGFAFLDTVVLVTGQDTIPSIQGAPGERTAPSTLPADTAFPPVTTLSPAHSSLAASPAHISNSTTQDNASDVLNASTTPSSLTPAKGIISTTDLTTTGPTSTHNPSCGDKYAGISVDYFYDKESETYNATLSEANNETLGCVKWVHVLQECEKKNINISCLSCYPPFKYLLEAPPGKYQLISVRAFTATLQFFPGIPQNMSCSNFSAHKGWVTWEPPENIFHTFTLCYWNLSEERCHTLNKTTNTINLEYLKPFTKYKITLHASVNGRVERNGTDVKCEAKTKATHPSKVKDLRVLWKTDNSMTVNCKPPDDFNGPETGKYHLIVSIGNNSAGKELKKEKCTFLVEGLQYSTEYTLKVFYHNGEYSGHPIIVSRSTSYNSNALIIFLVFLIIVTSIALLFVLYKIYDLQKKRSSNLDEQQELVERDDEKQLMHVEPIHADVLLETYKRKIADEGRLFLAEFQSIPRVFGKFSIKDARKPFNQNKNRYVDILPYDYNRVELSDINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNKNKCALYWPLMEEGSRVFGDVIVEINEHKRCPDYIIQKLTIANRKEKAAGRAVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPVVVHCSAGVGRTGTYIGIDAMLEGLEAESKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVSLSELHPYLSNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHTGNQEENKSKNRNSNVIPYDFNRVTLKHELEVSKESEHDSDESSDDDSDSEEMSKYINASFVMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKNGDQEVCSQYWEEGKQTYGDIEVHMKDTNKSSAYTIRAFELRHSKRKDPQTVYQYQFNNWNGEELPVEPKELILMIQNLKQKLPKKNSTEGNKFHRNVPLLIHCRDGSQQTGIFCALLNLLESAETEEVIDVFQAVKSLRKARPGMVPTFEQYQFLYDIIASTCPAQNGQVKKNNQQEDKIEFDNEVDKAKQDANCVSPPGALDKTPEGNKEDESSKPASGPEGPEHSANGPASPVLTQSA","proteome":"UP000265300","gene":"PTPRC","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004725","name":"protein tyrosine phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006470","name":"protein dephosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016311","name":"dephosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0050852","name":"T cell receptor signaling pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"8c053afb61557dfb5c0b749f6a1cea7ce5c221cc","counters":{"domain_architectures":255,"entries":31,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cdd":3,"smart":3,"cathgene3d":2,"ssf":2,"profile":3,"pfam":4,"panther":1,"prosite":1,"prints":1,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":255}}}