{"metadata":{"accession":"A0A2Z5U3H8","id":"A0A2Z5U3H8_PPVD","source_organism":{"taxId":"12212","scientificName":"Plum pox potyvirus (strain D)","fullName":"Plum pox potyvirus (strain D) (PPV)"},"name":"Genome polyprotein","description":["An RNA-dependent RNA polymerase that plays an essential role in the virus replication","Has RNA-binding and proteolytic activities","Has helicase activity. It may be involved in replication","Indispensable for virus replication","Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification","Mediates the cap-independent, EIF4E-dependent translation of viral genomic RNAs. Binds to the cap-binding site of host EIF4E and thus interferes with the host EIF4E-dependent mRNA export and translation. VPg-RNA directly binds EIF4E and is a template for transcription. Also forms trimeric complexes with EIF4E-EIF4G, which are templates for translation","Required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity"],"length":3140,"sequence":"MTTIVFGSFTCHLDAATHQDNADRLAKAWTRPENRQVSNVHLLCRRAAKSLINTYESATASAWKGLEEKLQPMFAKREFSKTVTKRKGLRCFKESSEKFIEKKLRKQYQEERERFQFLNGPDAIVNQISVDKCEASVWVPFPHIIEKPSFATPSMKKKVVFTKVRMAEASLQLFMRRVAANAKANGQKVEIIGRKRVVGSYTTKSRLTYFRAHVRHLDGSKPRYDLVLDEATKKILQLFANTSGFHHAHKKGEITPGMSGFVINPMNLSDPMQVYGTDLFIVRGKHNSILVDSRCTVSKEQSNEIIHYSDPGKQFWDGFTNSFMQCKLRETDHQCTSDLDVEECGYVAALVCQAIIPCGKITCLQCAQKYSYMSQQEIRDRFSTVIEQHEKTVMDNYPQFSHVLAFLKRYRELMRVENQNYEAFKDITHMIGERKEAPLSHLNKINELIIKGGMMSAQDYIEASDHLRELARYQKNRTENIRSGSIKAFRNKISSKAHVNMQLMCDNQLDTNGNFVWGQREYHAKRFFRNYFDVIDVSEGYRRHIVRENPRGIRKLAIGNLVMSTNLAALRKQLLGEECIHFEVSKECTSKRGENFVYQCCCVTHEDGTPLESEIISPTKNHLVVGNSGDSKYVDLPTAKGGAMFIAKAGYCYINIFLAMLININEDEAKSFTKTVRDTLVPKLGTWPSMMDLATACHFLAVLYPETRNAELPRILVDHEAKIFHVVDSFGSLPTGMHVLKANTINQLISFASDTLDSNMKTYLVGGLEVDKCDEFKNVKLLIRSIYKPQIMEQVLKEEPYLLLMSVLSPGVLMALFNSGSLEKATQYWITRSHSLAAITSMLSALAAKVSLASTLNAQMSVIDEHAAVLCDSVFDGTKPYASYMMAVKTLKRMKARTESVHTLNDLGFSVLRQATPHLVEKSYLQELEQAWKELSWSEKFSAILESQRWRKHIPKPFIPKDGADLGGRYDISVRSLLGNQYKRLRDVVRRKRDDVVCYTHQSMGKLFCKAIGVSTSFLPGTLKMLDMLIVFGLLLSIGATCNSMINEHKHLKQLAADREDKKRFKRLQVLYTRSSEKVGCTPTADEFLEYVGGENPDLLKHAEDLIGDGQVVVHQSKRDSQANLERVVAFVALVMMLFDSERSDGVYKILNKLKGIMGSVDQAVRHQSLDDIEDILDEKKLTVDFVLQSNEVAPTVPFDSTFEKWWTNQLETGNVIPHYRTEGYFLEFTRENAAHIANEVVHGSHQDILIRGAVGSGKSTGLPFHLSKKGHVLLIEPTRPLAENVCKQLRGQPFNVNPTLRMRGMSTFGSTPITVMTSGYALHFLANNPTYLDNYKCIIFDECHVHDASAMAFRCLLSEYSYPGKILKVSATPPGHEVDFKTQKEVKVIVEESLSFQQFVSNLGTGCNSDILKHGVNVLVYVASYNEVDTLSKLLTDRSFKVSKVDGRTMKVGNVEIPTSGTQAKPHFVVATNIIENGVTLDIDVVVDFGLKVVPVLDIDNRLVRYTKKSISYGERIQRLGRVGRNKPGAALRIGFTEKGLTQIPPIIATEAAFLCFTYGLPVMTNGVSTSLLAMCTVKQARTMQQFELSPFYTVALVRFDGTMHQEIFRLLKSYRLRDSEVVLNKLAIPNSNVCGWMSVRDYKRQGCNLDLDEDIRVPFYVKDIPETLHEKIWQAVETHKSDAGFGRICSSSACKIAYTLQTDIHSIPRTVKIIDALLEQERTKQAHFRAMTSQSCSSSNFSLSSITSAIRSKYAKDHTEENIGVLQMAKSQLLEFKNLNIDPSYPELVRNFGALECVHHQTKEGVSNALQLKGHWNKRLITRDATLMLGVLGGGAWMIFSYLRDSFKEEVVHQGFNRRQRQKLKFRQARDNRMVREVYGDDSTMEDYFGSAYSKKGKSKGKTRGMGTKTRKFVNMYGYDPTDYNFVRFVDPLTGHTLDENPLMDINLVQEHFSQIRNDYIGDDKITMRHIMSNPGIVAYYIKDATQKALKVDLTPHNPLRVCDKTATIAGFPEREFELRQTGHPVFVEPNAVPKINEEGDGEVDHDSKSLFRGLRDYNPIASSICQLNNSSGARQSEMFGLGFGGLIVTNQHLFKRNDGELTIRSHHGEFVVKDTKTLKLLPCKGRDIVITRLPKDFPPFPKRLQFRTPTTEDRVCLIGSNFQTKSISSTMSETSTTYPVDNSHFWKHWISTKDGHCGLPIVSTRDGSILGLHSLANSTNTQNFYAAFPDNFETTYLSNQDNDNWTKQWRYNPDEVCWGSLQLKRDIPQSPFTICKLLTDLDGEFVYTQSKTTHWLRDRLEGNLKAVGACPGQLVTKHVVKGKCTLFETYLLTHPEEHEFFRPLMGAYQKSALNKDAYVKDLMKYSKPIVVGAVDCDQFERAVDVVISMLISKGFEECNYVTDPDDIFSALNMKAAVGALYSGKKRDYFKDVSDQDKESFVRASCKRLFMGKKGVWNGSLKAELRPKEKVEANKTRSFTAAPIDTLLGGKVCVDDFNNQFYSLNLHCPWSVGMTKFRGGWDKLLRALPEGWIYCDADGSQFDSSLSPYLINAVLNIRLAFMEEWDIGEQMLSNLYTEIVYTPIATPDGTIVKKFKGNNSGQPSTVVDNTLMVILAMTYSLLKLGYHPDTHDCICRYFVNGDDLVLAVHPAYESIYDELQEHFSQLGLNYTFATKTENKEELWFMSHKGVLYDDMYIPKLEPERIVSILEWDRSNEPIHRLEAICASMVEAWGYKELLREIRKFYSWVLEQAPYNALSKDGKAPYIAETALKKLYTDTEASETEIERYLEAFYNDINDDGESNVVVHQADEREDEEEVDAGKPIVVTAPAATSPMLQPPPVIQPTPRTTAPMFNPIFTPATTQPATKPVPQVSGPQLQTFGTHGNEDASPSNSNALVNTNRDRDVDAGSIGTFTVPRLKAMTSKLSLPKVKGKAIMNLNHLAHYSPAQVDLSNTRAPQSCFQTWYEGVKRDYDVTDDEMSIILNGLMVWCIENGTSPNINGMWVMMDGETQVEYPIKPLLDHAKPTFRQIMAHFSNVAEAYIEKRNYEKAYMPRYGIQRNLTDYSLARYAFDFYEMTSTTPVRAREAHIQMKAAALRNAQNRLFGLDGNVGTQEEDTERHTAGDVNRNMHNLLGVRGV","proteome":null,"gene":null,"go_terms":[{"identifier":"GO:0004197","name":"cysteine-type endopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006508","name":"proteolysis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008234","name":"cysteine-type peptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003968","name":"RNA-directed RNA polymerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0039694","name":"viral RNA genome replication","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005198","name":"structural molecule activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016818","name":"hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0018144","name":"RNA-protein covalent cross-linking","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006351","name":"DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0019028","name":"viral capsid","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"540c45df77e47beb363c4ab9fa44ae70c9fcb5f4","counters":{"domain_architectures":3385,"entries":44,"isoforms":0,"proteomes":0,"sets":5,"structures":0,"taxa":1,"dbEntries":{"profile":6,"cathgene3d":4,"smart":2,"ssf":3,"pfam":9,"cdd":1,"panther":1,"prints":1,"interpro":17},"proteome":0,"taxonomy":1,"similar_proteins":3385}}}