{"metadata":{"accession":"A0A2Y9STY5","id":"A0A2Y9STY5_PHYMC","source_organism":{"taxId":"9755","scientificName":"Physeter macrocephalus","fullName":"Physeter macrocephalus (Sperm whale)"},"name":"Tuberin","description":["Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1. Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5"],"length":1822,"sequence":"MAKPASKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSVECGLNNRIRVIGQICEVAKTKKFEEAVSRCPVDRVGSCLPLEFLKGSALASTHFCHAVEALWKAVSDLLQPERPPEARHAVLALLKAIVQGQGDRLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELAEFVLQWMDIGLSSEFLLVLVNLVKFNSCYLDEYIASMVHMICLLCVQTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYHMCRIMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSITRLIKKYRRELQAVTWDILLKIVERLLQQLQSLDSPELRAIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPESSLLNLITYRAQSIHPAKDGWIHNLQLLMERFFRNELRSAVRIKVLDVLSFVLLINRQFYEEELINLVVISQLSHVPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVIARSLSPPPELEERDVVVYSASLEDVKTAVLGLLVILQTKLYALPASHATRVYETLVSHIQLHYKHTYTLPIASSIRLQAFDFLLQLRADSLHRLGLPSKDGLVRFSPYCVCDYMEPERGSEKKAGGPLSPPTGPPGPAPAVPAVRLGSLPYSLLFRVLLQCLKQETDWKVLKLVLSKLPESLRYKVLIFTSPCNVDQLSAALCSMLSGPKTLERLRSTPEGFSRTDLHLAVVPVLTALISYHNYLDKTRQREMVYCLEQGLIYRCASQCVVALAICSVEMPDIIIKALPVLVVKLTHISATASMAIPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPYITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNSPPVKEFKESSAADAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSMAQADDNLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQGGPELSSDPSVHVRQTKEAPAKLESQAGQQVCRGARDRVRSMSGGHGLRVGALDAPASHFPGSPACLGSQTAPASKPEKASASTQLPAQKEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNTPLQELSNALMAAERFKERRDTALYKSLSVPAAGSAKPPPPPRSNTDSAVVLEEGSPGEASLPVEPPELEDFEATLGTDGHYRHAEAFSRSSSTSSQEEKSFHAEELAAGGIPIERAVSSEGSRPSVELAFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEAKARSQSGILDREGASWSAPGEESQGQGPTQPEGPLPSTCPRSPSGLRPRGYTISDSAPSRRGKRVERDAFRSRAGTSNTEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGKLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIITPLDYECNLVSLQCRKDMEGLVDTSMAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDTYPSKWIARLRHIKRLRHRIREEAHYSNASLPLMQTHPPGHAKAPTQAPVEPTPTYETGQRKRLVSSVDDFTEFV","proteome":"UP000248484","gene":"TSC2","go_terms":[{"identifier":"GO:0005096","name":"GTPase activator activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051056","name":"regulation of small GTPase mediated signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0043547","name":"positive regulation of GTPase activity","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0032007","name":"negative regulation of TOR signaling","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0033596","name":"TSC1-TSC2 complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"f74181c50b462dc72aee9d8137b7bec3a5d0e532","counters":{"domain_architectures":3654,"entries":18,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cathgene3d":2,"profile":1,"pfam":3,"panther":1,"prints":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":3654}}}