{"metadata":{"accession":"A0A2Y9RCW0","id":"A0A2Y9RCW0_TRIMA","source_organism":{"taxId":"127582","scientificName":"Trichechus manatus latirostris","fullName":"Trichechus manatus latirostris (Florida manatee)"},"name":"Apoptosis regulator Bcl-2","description":["Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function. May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release"],"length":188,"sequence":"MAHAGRTGYDNREIVMKYIHYKLSQRGYEWEAGDASAASPEAAPEPGVFSSPPDAPRGPAARTSPLPPAPAAQPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWGIF","proteome":"UP000248480","gene":"BCL2","go_terms":[{"identifier":"GO:0042981","name":"regulation of apoptotic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0043066","name":"negative regulation of apoptotic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e6df88747055402b85860b0fcaeda48c25af010f","counters":{"domain_architectures":1961,"entries":24,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"smart":2,"profile":2,"cdd":1,"panther":1,"pfam":2,"prosite":3,"prints":2,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":1961}}}