{"metadata":{"accession":"A0A2Y9EYT3","id":"A0A2Y9EYT3_PHYMC","source_organism":{"taxId":"9755","scientificName":"Physeter macrocephalus","fullName":"Physeter macrocephalus (Sperm whale)"},"name":"Hepatocyte nuclear factor 1-beta","description":["Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene. Transcriptional activity is increased by coactivator PCBD1"],"length":558,"sequence":"MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPSFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREILRQFNQTVQSSGNLTDKSSQDQLLFLFPEFSQQSQGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSSQTHGLNPLLSHGSPPHQPSTSPPNKLPGVRYSQQGNNEVTSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHNLLSPDGKMQISVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQSLNSSQAQSVPVINSVAGSLAALQPVQFSQQLHSSHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSISTLTNMSSSKQCPLQAW","proteome":"UP000248484","gene":"HNF1B","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0001889","name":"liver development","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006357","name":"regulation of transcription by RNA polymerase II","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0030073","name":"insulin secretion","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0031016","name":"pancreas development","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0045893","name":"positive regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e2a0d68890c584f7f2bfd7a867fa9deda5d4213b","counters":{"domain_architectures":1409,"entries":22,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":3,"profile":3,"cathgene3d":2,"smart":1,"cdd":1,"panther":1,"pfam":2,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":1409}}}