{"metadata":{"accession":"A0A2Y9E6S2","id":"A0A2Y9E6S2_TRIMA","source_organism":{"taxId":"127582","scientificName":"Trichechus manatus latirostris","fullName":"Trichechus manatus latirostris (Florida manatee)"},"name":"Metalloprotease TIKI","description":["Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation"],"length":514,"sequence":"MRPWSWFLLPTLCLRPTGAAQPRGVLASANCELKPQQSELNSFLWTIKRDLLSYFFGTIHVPYTRVWDFIPDNSKEAFQQSSIVYLELDLTNPYTISALTSCQMLLQGENLQDVLPRDIYCCLKCHLEYVKLTMPSWMTPDQHGKGLYADYLFSAITGNWERKRPIWVMLMVNSLTEVDIKSCGVPVLDLYLVQEAERLRKQTGAVEKVEEQCHPLNGLNFSQVILALNQKLLQQESLXAGSVQIPYTMKDLIKHYNCGDLRSIIFSHDSSQVPNFINATLPPQECVTAQEIDSYFRQELIYKRNERMGKRVKALLEEFPNKSFLFAFGAGHFMGNNTVLDVLRREGYEVEHAPAGQPINKGRSKAPSPNPALSAIFAPEVPAPTPPVPEAGSEAPLLLPPHASSSGSADLPIXAERKFRKKWRRLLRRQQLREFSELWVRLEESAVVPHLQVPILDRHISTELRFPRQGHFHHSQMVASHACLSLWTPVFWVLVLALQTDSPPVMAGAARPRP","proteome":"UP000248480","gene":"TRABD2A","go_terms":[{"identifier":"GO:0004175","name":"endopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030178","name":"negative regulation of Wnt signaling pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"65094d78d77d68ebfb4b6056561de2a19ab2ee0e","counters":{"domain_architectures":17551,"entries":5,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"panther":1,"pfam":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":17551}}}