{"metadata":{"accession":"A0A2K6UC84","id":"A0A2K6UC84_SAIBB","source_organism":{"taxId":"39432","scientificName":"Saimiri boliviensis boliviensis","fullName":"Saimiri boliviensis boliviensis (Bolivian squirrel monkey)"},"name":"Vacuolar proton pump subunit B","description":["Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment","Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment. The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment. In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load"],"length":511,"sequence":"MALRAMRGIVNGAAPELPVPAGGPAVGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFERNFIAQGPYENRTVYETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH","proteome":"UP000233220","gene":null,"go_terms":[{"identifier":"GO:0046034","name":"ATP metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:1902600","name":"proton transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0046961","name":"proton-transporting ATPase activity, rotational mechanism","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0033180","name":"proton-transporting V-type ATPase, V1 domain","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"d079caac124722904c86efe2303dd63e1f2836bb","counters":{"domain_architectures":31161,"entries":21,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cdd":3,"pfam":3,"cathgene3d":1,"ssf":1,"panther":1,"pirsf":1,"hamap":1,"ncbifam":2,"prosite":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":31161}}}