{"metadata":{"accession":"A0A2K6P708","id":"A0A2K6P708_RHIRO","source_organism":{"taxId":"61622","scientificName":"Rhinopithecus roxellana","fullName":"Rhinopithecus roxellana (Golden snub-nosed monkey)"},"name":"Rab GDP dissociation inhibitor","description":["GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A","Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP"],"length":445,"sequence":"MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESASITPLEDLYKRFKIPGSPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVTEGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEGIDPKKTTMREVYKKFDLGQDVIDFTGHALALYRTDDYLDQPCYETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLLVPKDLGMESQIFISRTYDATTHFETTCDDIKNIYKRMTGSEFDFEEMKRKKNDIYGED","proteome":"UP000233200","gene":"GDI2","go_terms":[{"identifier":"GO:0005092","name":"GDP-dissociation inhibitor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007264","name":"small GTPase-mediated signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005093","name":"Rab GDP-dissociation inhibitor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0015031","name":"protein transport","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"bf4a0619627864712015915d155a6b211ace67a2","counters":{"domain_architectures":9748,"entries":11,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":3,"pfam":1,"panther":1,"prints":2,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":9748}}}