{"metadata":{"accession":"A0A2K5UZV2","id":"A0A2K5UZV2_MACFA","source_organism":{"taxId":"9541","scientificName":"Macaca fascicularis","fullName":"Macaca fascicularis (Crab-eating macaque)"},"name":"Histamine H2 receptor","description":["G-protein coupled receptor for histamine, primarily mediating gastric acid secretion. Predominantly expressed in the gastric mucosa, couples to G(s) G alpha proteins upon histamine binding, leading to activation of adenylate cyclase and increased intracellular cyclic AMP (cAMP) levels. This signaling cascade stimulates parietal cells to secrete hydrochloric acid, playing a key role in digestive physiology. Also expressed in other tissues, including the heart and central nervous system, where it may contribute to cardiac stimulation and modulate neurotransmitter release"],"length":422,"sequence":"MAPNGTASSFCLDSTACKITITVVLAVLILITIAGNVVVCLAVGLNRRLRNLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHRTSVRSNASQLSRTQSREPRQQEDKPLKLQVWSGTEVTAPQGATDRKPALSCTTCSSNLLSCSKSLWGLRFLQRHMGGPSEEPSGEPLSEEPQKRPPQKAVRTLPSEAV","proteome":"UP000233100","gene":null,"go_terms":[{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004969","name":"histamine receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0001696","name":"gastric acid secretion","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0045907","name":"positive regulation of vasoconstriction","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"587fa3dbe4504dc051049f3cca904dd9ab631b87","counters":{"domain_architectures":340616,"entries":13,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"smart":1,"pfam":1,"profile":1,"panther":1,"prints":2,"prosite":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":340616}}}