{"metadata":{"accession":"A0A2J8RIW8","id":"A0A2J8RIW8_PONAB","source_organism":{"taxId":"9601","scientificName":"Pongo abelii","fullName":"Pongo abelii (Sumatran orangutan)"},"name":"Adenosine deaminase 2","description":["Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity"],"length":511,"sequence":"MLVDGPSEWPALRFLLLAVAMSFFGSALSIDETRAHLLLKEKMMRLGGRLVLNTKEEQANERLMMLKIAEMKEAMRTLIFPPSMHFFQAKHLIERSQVFNILRMMPKGAALHLHDIGIVTMDWLVRNVTYRPHCHICFTPKGIMQFRFAHPTPRTSEKCSKWILLEDYRKRVQNVTEFDDSLLRNFTLVTQHPEVIYTNQNVVWSKFETIFFTISGLIHYAPVFRDYVFQSMQEFYEDNVLYMEIRARLLPVYELSGEHHDEEWSVKTYQEVAQKFVETHPEFIGIKIIYSDHRSKDVAVIAESIRTAMGLRTKFPTVVAGFDLVGHEDTGHSLHDYKEALMIPAKGGVKLPYFFHAGETDWQGTSIDRNILDALMLNTTRIGHGFALSKHPAVRAYSWKKDIPIEVCPISNQVLKLVSDLRNHPVATLMATGHPMVISSDDPAIFGAKGLSYDFYEVFMGIGGMKADLRTLKQLAMNSIKYSALLEIEKNTFMEIWKKRWDKFIADVATK","proteome":"UP000001595","gene":"ADA2","go_terms":[{"identifier":"GO:0019239","name":"deaminase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005615","name":"extracellular space","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004000","name":"adenosine deaminase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006154","name":"adenosine catabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"250157578b179d9a90636b0f6ca6c661cd82188e","counters":{"domain_architectures":1912,"entries":12,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"ssf":1,"pfam":2,"ncbifam":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":1912}}}