{"metadata":{"accession":"A0A2I4BN29","id":"A0A2I4BN29_AUSLI","source_organism":{"taxId":"52670","scientificName":"Austrofundulus limnaeus","fullName":"Austrofundulus limnaeus (Annual killifish)"},"name":"Protein zwilch","description":["Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex"],"length":484,"sequence":"MGSRVISRAKMFFSVLRSFQEGSSDSCSYEDDIQILKINGNKIAAVNLYCGSQTVFVCEKAVPKLSEPDDEQVIERSESDADDGCDVLQNEQGPQPLTVTKARQLLSLYTLFQNSGVSAVDSSFVLHPLWVRCDMSDPAGTTWFGAEPVCVGNKVTGVKLYSVTCKGSTVDKPSLLTLEELKQEHKKRHHPSSMGLKGNARFSLFGSTVFENTIIESQSSVTVDFKWSHVESVLEAPPLSSTATMNIKVASGDMRSPMFEMYRELEFLRSLADCLKTGETEWMEPIESTSAVNVTKAYLEELKTTAITSQDQAAKTAELKSETDPPIFNCFLERGNLDFVEQLWIRLRKSVTSYEDIRDSLKLVIEALRYDDIKPWIHRDSSSSLSKLILQSYHQQIEHVSLTGVTPIIMLLEMGLDKMRKDYINYLIGEELTTLNHLCYFLSTEVDLQEQVVRLRKLHHLLEIIVTCGTFLALPYDRLFLLTQ","proteome":"UP000192220","gene":"LOC106521209","go_terms":[{"identifier":"GO:0007093","name":"mitotic cell cycle checkpoint signaling","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:1990423","name":"RZZ complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7e8dc56355427df32da3f919291fc4bfff0ed7b9","counters":{"domain_architectures":1571,"entries":7,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"panther":1,"pfam":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":1571}}}