{"metadata":{"accession":"A0A091PS84","id":"A0A091PS84_HALAL","source_organism":{"taxId":"8969","scientificName":"Haliaeetus albicilla","fullName":"Haliaeetus albicilla (White-tailed sea-eagle)"},"name":"Chloride intracellular channel protein","description":["In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3"],"length":232,"sequence":"LLQAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITYNGEVKTDVNKIEEFLEDVLAPPKYLKLSPKHPESNTAGMDIFAKFSAFIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDITISTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFEIPKEMTGIWRYLTNAYSRDEFTNTCPGDKEIEIAYSDVAKRLTK","proteome":null,"gene":"N329_08395","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6cae92723920465a0b88d6551dcf65ad4af8bf8b","counters":{"domain_architectures":2832,"entries":19,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cdd":2,"cathgene3d":2,"pfam":1,"ssf":2,"profile":1,"panther":1,"ncbifam":1,"sfld":2,"prints":1,"interpro":6},"proteome":0,"taxonomy":1,"similar_proteins":2832}}}