{"metadata":{"accession":"A0A076EBV7","id":"A0A076EBV7_OCHPR","source_organism":{"taxId":"9978","scientificName":"Ochotona princeps","fullName":"Ochotona princeps (Southern American pika)"},"name":"Interleukin-6","description":["Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells"],"length":216,"sequence":"MNSVFASALRPAPVGFALGLLLVVATAFPTAPSVSMKEEPQGGATSDKPFTPVKIESTISYILMKISDIRKKMCNYDANCLDCKQVLSDVNLTLPQLTERDGCFPSAPNQEICLMRITAGLLEFEIYLKHLQNKFKSDEENNNMDIVLQNSQTLVKTLRPKVKTTEEAPTLEPATLTSLKENMQLKEQWRRTQTIHYILCGLKDFLEFTLRAVRLM","proteome":null,"gene":"IL6","go_terms":[{"identifier":"GO:0005138","name":"interleukin-6 receptor binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030154","name":"cell differentiation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005615","name":"extracellular space","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005125","name":"cytokine activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006955","name":"immune response","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005576","name":"extracellular region","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ca3c816964203ca148b2a41a888b8b5a391e3f49","counters":{"domain_architectures":1063,"entries":12,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pfam":1,"ssf":1,"smart":1,"panther":1,"prints":2,"prosite":1,"interpro":4},"proteome":0,"taxonomy":1,"similar_proteins":1063}}}