{"metadata":{"accession":"PF22513","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR053853","hierarchy":null,"name":{"name":"Antitoxin FitA-like, ribbon-helix-helix","short":"FitA-like_RHH"},"description":[{"text":"<p>This domain is found in Antitoxin FitA from Neisseria gonorrhoeae and similar bacterial sequences. FitA is the antitoxin component of a type II toxin-antitoxin (TA) system. It binds DNA through its ribbon-helix-helix motif (this entry) [[cite:PUB00039746]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00039746":{"PMID":16982615,"ISBN":null,"volume":"281","issue":"49","year":2006,"title":"Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs.","URL":null,"raw_pages":"37942-51","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Mattison K","Wilbur JS","So M","Brennan RG."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M605198200"}},"set_info":{"accession":"CL0057","name":"Met_repress"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":16,"interactions":0,"matches":5352,"pathways":0,"proteins":5350,"proteomes":2800,"sets":1,"structural_models":{"alphafold":3973,"bfvd":0},"structures":3,"taxa":5438},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":313,"alignment:full":2149},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7e4j","name":"X-ray crystal structure of VapB12 antitoxin from mycobacterium tuberculosis in space group P41."}}}