{"metadata":{"accession":"PF22195","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR054019","hierarchy":null,"name":{"name":"CFP-like, C-terminal thrombospondin type 1 domain","short":"TSP1_CFP_C"},"description":[{"text":"<p>This domain is found at the C-terminal end of human Properdin (CFP, for Complement factor P) and similar animal proteins. CFP is a positive regulator of the alternate pathway (AP) of complement. It contains six thrombospondin repeat type I (TSP 1-6 domains and an N-terminal domain ([pfam:PF18487]). This entry represents the last TSP type I domain, which binds to the first TSP type I domain ([pfam:PF00090]), contributing to multimerisation [[cite:PUB00027123],[cite:PUB00038006],[cite:PUB00153864],[cite:PUB00153865],[cite:PUB00153866]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00153866":{"PMID":31552043,"ISBN":null,"volume":"10","issue":null,"year":2019,"title":"Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.","URL":null,"raw_pages":"2097","medline_journal":"Front Immunol","ISO_journal":"Front Immunol","authors":["van den Bos RM","Pearce NM","Granneman J","Brondijk THC","Gros P."],"DOI_URL":"https://doi.org/10.3389/fimmu.2019.02097"},"PUB00153864":{"PMID":21821127,"ISBN":null,"volume":"80","issue":"2","year":2011,"title":"Expression, purification and structural characterization of functionally replete thrombospondin-1 type 1 repeats in a bacterial expression system.","URL":null,"raw_pages":"253-9","medline_journal":"Protein Expr Purif","ISO_journal":"Protein Expr Purif","authors":["Klenotic PA","Page RC","Misra S","Silverstein RL."],"DOI_URL":"https://doi.org/10.1016/j.pep.2011.07.010"},"PUB00038006":{"PMID":15491616,"ISBN":null,"volume":"343","issue":"5","year":2004,"title":"The dimeric and trimeric solution structures of the multidomain complement protein properdin by X-ray scattering, analytical ultracentrifugation and constrained modelling.","URL":null,"raw_pages":"1327-43","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Sun Z","Reid KB","Perkins SJ."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2004.09.001"},"PUB00027123":{"PMID":12391027,"ISBN":null,"volume":"159","issue":"2","year":2002,"title":"Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication.","URL":null,"raw_pages":"373-82","medline_journal":"J Cell Biol","ISO_journal":"J. Cell Biol.","authors":["Tan K","Duquette M","Liu JH","Dong Y","Zhang R","Joachimiak A","Lawler J","Wang JH."],"DOI_URL":"http://dx.doi.org/10.1083/jcb.200206062"},"PUB00153868":{"PMID":36173177,"ISBN":null,"volume":"31","issue":"10","year":2022,"title":"Structure determination of an unstable macromolecular complex enabled by nanobody-peptide bridging.","URL":null,"raw_pages":"e4432","medline_journal":"Protein Sci","ISO_journal":"Protein Sci","authors":["Lorentzen J","Pedersen DV","Gadeberg TAF","Andersen GR."],"DOI_URL":"https://doi.org/10.1002/pro.4432"},"PUB00153865":{"PMID":31507604,"ISBN":null,"volume":"10","issue":null,"year":2019,"title":"Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.","URL":null,"raw_pages":"2007","medline_journal":"Front Immunol","ISO_journal":"Front Immunol","authors":["Pedersen DV","Gadeberg TAF","Thomas C","Wang Y","Joram N","Jensen RK","Mazarakis SMM","Revel M","El Sissy C","Petersen SV","Lindorff-Larsen K","Thiel S","Laursen NS","Fremeaux-Bacchi V","Andersen GR."],"DOI_URL":"https://doi.org/10.3389/fimmu.2019.02007"},"PUB00153867":{"PMID":35031611,"ISBN":null,"volume":"13","issue":"1","year":2022,"title":"Structure and function of a family of tick-derived complement inhibitors targeting properdin.","URL":null,"raw_pages":"317","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Braunger K","Ahn J","Jore MM","Johnson S","Tang TTL","Pedersen DV","Andersen GR","Lea SM."],"DOI_URL":"https://doi.org/10.1038/s41467-021-27920-2"}},"set_info":{"accession":"CL0692","name":"TSP1"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":33,"interactions":0,"matches":585,"pathways":0,"proteins":583,"proteomes":356,"sets":1,"structural_models":{"alphafold":546,"bfvd":0},"structures":13,"taxa":1332},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":417},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}