{"metadata":{"accession":"PF20644","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR048540","hierarchy":null,"name":{"name":"Rrn7/TAF1B, N-terminal cyclin domain","short":"Rrn7_cyclin_N"},"description":[{"text":"<p>Rrn7 from yeast and its orthologue TATA box-binding protein-associated factor RNA polymerase I subunit B (TAF1B) from human, are TFIIB-like factors components of RNA polymerase I core factor complex. They contain two cyclin fold domains which interact with both Rrn6 and Rrn11 and form the fingers of the core factor which resembles a right hand. N-terminal regions of both Rrn11 and Rrn6 compose the palm, the thumb is composed by the C-terminal of Rrn11 and the knuckles consist of the C-terminal half of Rrn6. This is the first cyclin domain (cyclin I) from yeast Rrn7 and its orthologues from animals and plants TAF1B [[cite:PUB00099775],[cite:PUB00100002]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100002":{"PMID":28623663,"ISBN":null,"volume":"6","issue":null,"year":2017,"title":"Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.","URL":null,"raw_pages":null,"medline_journal":"Elife","ISO_journal":"Elife","authors":["Han Y","Yan C","Nguyen THD","Jackobel AJ","Ivanov I","Knutson BA","He Y."],"DOI_URL":null},"PUB00099775":{"PMID":28340337,"ISBN":null,"volume":"169","issue":"1","year":2017,"title":"Structural Basis of RNA Polymerase I Transcription Initiation.","URL":null,"raw_pages":"120-131.e22","medline_journal":"Cell","ISO_journal":"Cell","authors":["Engel C","Gubbey T","Neyer S","Sainsbury S","Oberthuer C","Baejen C","Bernecky C","Cramer P."],"DOI_URL":null}},"set_info":{"accession":"CL0065","name":"Cyclin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":77,"interactions":0,"matches":3296,"pathways":0,"proteins":3216,"proteomes":2345,"sets":1,"structural_models":{"alphafold":2857,"bfvd":0},"structures":17,"taxa":6401},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":18,"alignment:full":2249},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}