{"metadata":{"accession":"PF16282","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR032563","hierarchy":null,"name":{"name":"SANT/Myb-like domain of DAMP1","short":"SANT_DAMP1_like"},"description":[{"text":"<p>This domain, approximately 90 residues, is mainly found in DNA methyltransferase 1-associated protein 1 (DAMP1) that plays an important role in development and maintenace of genome integrity in various mammalia species [[cite:PUB00063468],[cite:PUB00076522]]. It mainly consists of tandem repeats of three alpha-helices that are arranged in a helix-turn-helix motif and shows a structual similarity with SANT domain and Myb DNA-binding domain, indicating it contains a putative DNA binding site [[cite:PUB00005459]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00076522":{"PMID":21383065,"ISBN":null,"volume":"31","issue":"9","year":2011,"title":"Distinct roles of DMAP1 in mouse development.","URL":null,"raw_pages":"1861-9","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Mohan KN","Ding F","Chaillet JR."],"DOI_URL":"http://dx.doi.org/10.1128/MCB.01390-10"},"PUB00063468":{"PMID":19845771,"ISBN":null,"volume":"14","issue":"11","year":2009,"title":"Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process.","URL":null,"raw_pages":"1347-57","medline_journal":"Genes Cells","ISO_journal":"Genes Cells","authors":["Negishi M","Chiba T","Saraya A","Miyagi S","Iwama A."],"DOI_URL":"http://dx.doi.org/10.1111/j.1365-2443.2009.01352.x"},"PUB00005459":{"PMID":8882580,"ISBN":null,"volume":"21","issue":"3","year":1996,"title":"The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB.","URL":null,"raw_pages":"87-8","medline_journal":"Trends Biochem Sci","ISO_journal":"Trends Biochem. Sci.","authors":["Aasland R","Stewart AF","Gibson T."],"DOI_URL":"http://dx.doi.org/10.1016/0968-0004(96)30009-1"}},"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":58,"interactions":0,"matches":4703,"pathways":0,"proteins":4697,"proteomes":3167,"sets":1,"structural_models":{"alphafold":4228,"bfvd":0},"structures":19,"taxa":8977},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":97,"alignment:full":3094},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4iej","name":"Crystal structure of a DNA methyltransferase 1 associated protein 1 (DMAP1) from Homo sapiens at 1.45 A resolution"}}}