{"metadata":{"accession":"PF11569","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024578","hierarchy":null,"name":{"name":"Homeodomain leucine-zipper encoding, Homez","short":"Homez"},"description":[{"text":"<p>Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus [[cite:PUB00056069]]. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerisation and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain [[cite:PUB00056069]]. Homez is involved in a complex regulatory network [[cite:PUB00056069]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00056069":{"PMID":12925734,"ISBN":null,"volume":"100","issue":"18","year":2003,"title":"Homez, a homeobox leucine zipper gene specific to the vertebrate lineage.","URL":null,"raw_pages":"10358-63","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Bayarsaihan D","Enkhmandakh B","Makeyev A","Greally JM","Leckman JF","Ruddle FH."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.1834010100"}},"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":28,"interactions":0,"matches":1945,"pathways":0,"proteins":1945,"proteomes":717,"sets":1,"structural_models":{"alphafold":1732,"bfvd":0},"structures":1,"taxa":2223},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":1411},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}