Med19 represents a family of conserved proteins which are members of the multi-protein co-activator Mediator complex. Mediator is required for activation of RNA polymerase II transcription by DNA binding transactivators [[cite:PUB00014721]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Mediator_(coactivator)","extract":"Mediator is a multiprotein complex that functions as a transcriptional coactivator in all eukaryotes. It was discovered in 1990 in the lab of Roger D. Kornberg, recipient of the 2006 Nobel Prize in Chemistry. Mediator interacts with transcription factors and RNA polymerase II. It mainly functions to transmit signals from the transcription factors to the polymerase.
","thumbnail":null}],"literature":{"PUB00014721":{"PMID":12584197,"ISBN":null,"volume":"278","issue":"17","year":2003,"title":"Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.","URL":null,"raw_pages":"15123-7","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Sato S","Tomomori-Sato C","Banks CA","Sorokina I","Parmely TJ","Kong SE","Jin J","Cai Y","Lane WS","Brower CS","Conaway RC","Conaway JW."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.C300054200"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":22,"interactions":0,"matches":1763,"pathways":0,"proteins":1730,"proteomes":1185,"sets":0,"structural_models":{"alphafold":1582,"bfvd":0},"structures":12,"taxa":4203},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":1225},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}