{"metadata":{"accession":"PTHR21181","entry_id":null,"type":"family","go_terms":null,"source_database":"panther","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"ER Membrane Protein Complex Subunit","short":"ER_Membrane_Complex_Subunit"},"description":[{"text":"This family of proteins is involved in the biogenesis and assembly of membrane proteins and complexes. Members of this family are part of the endoplasmic reticulum membrane protein complex (EMC), which facilitates the insertion of newly synthesized membrane proteins into the endoplasmic reticulum (ER) membrane. This process is energy-independent and can accommodate transmembrane domains with various features, including weak hydrophobicity and destabilizing residues like charges and aromatics. The family plays a role in the cotranslational insertion of multi-pass membrane proteins and the post-translational insertion of tail-anchored proteins into the ER membrane. It is also implicated in determining the topology of multi-pass membrane proteins, such as G protein-coupled receptors, by ensuring the correct orientation of N-terminal transmembrane domains. Additionally, some members may be involved in magnesium transport across membranes.","llm":true,"checked":false,"updated":false}],"wikipedia":null,"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":4,"domain_architectures":0,"interactions":0,"matches":4571,"pathways":0,"proteins":4571,"proteomes":2336,"sets":0,"structural_models":{"alphafold":4121,"bfvd":0},"structures":9,"taxa":7043},"entry_annotations":{"hmm":0,"logo":0},"cross_references":{},"is_llm":true,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}