{"metadata":{"accession":"TIGR02254","entry_id":null,"type":"family","go_terms":null,"source_database":"ncbifam","member_databases":null,"integrated":"IPR011951","hierarchy":null,"name":{"name":"noncanonical pyrimidine nucleotidase, YjjG family","short":"YjjG_YfnB"},"description":[{"text":"<p>This HAD superfamily includes including YjjG from E. coli and YfnB from B. subtilis. YjjG has been shown to act as a house-cleaning enzyme, cleaving nucleotides with non-canonical nucleotide bases. This family is a member of the haloacid dehalogenase (HAD) superfamily of hydrolases which are characterized by three conserved sequence motifs [2]. By virtue of an alpha helical domain in-between the first and second conserved motif, this family is a member of subfamily IA (TIGR01549).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00003337":{"PMID":7966317,"ISBN":null,"volume":"244","issue":"1","year":1994,"title":"Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search.","URL":null,"raw_pages":"125-32","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Koonin EV","Tatusov RL."],"DOI_URL":"http://dx.doi.org/10.1006/jmbi.1994.1711"},"PUB00070801":{"PMID":17286574,"ISBN":null,"volume":"270","issue":"1","year":2007,"title":"The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.","URL":null,"raw_pages":"49-57","medline_journal":"FEMS Microbiol Lett","ISO_journal":"FEMS Microbiol. Lett.","authors":["Titz B","Hauser R","Engelbrecher A","Uetz P."],"DOI_URL":"http://dx.doi.org/10.1111/j.1574-6968.2007.00646.x"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":7238,"pathways":0,"proteins":7238,"proteomes":4225,"sets":0,"structural_models":{"alphafold":5673,"bfvd":0},"structures":3,"taxa":7050},"entry_annotations":{"hmm":0,"logo":0},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3qnm","name":"Haloalkane Dehalogenase Family Member from Bacteroides thetaiotaomicron of Unknown Function"}}}