The extended synaptotagmin (E-Syt) family includes a group of Ca2+-regulated intrinsic membrane proteins, such as E-Syt1, E-Syt2 and E-Syt3. They are composed of an N-terminal endoplasmic reticulum (ER)-membrane anchor, a central SMP-domain, and five (E-Syt1) or three C-terminal cytoplasmic C2-domains (E-Syt2 and E-Syt3). The ER-membrane anchor and C2 domains are required for tethering, while the SMP domain is a lipid-binding domain that links the ER with other lipid bilayer-membranes within the cell. This model corresponds to the SMP domain, which has a beta-barrel structure like protein modules in the tubular-lipid-binding (TULIP) superfamily. It dimerizes to form an approximately 90-Angstrom-long cylinder traversed by a channel lined entirely with hydrophobic residues. The following two C2 domains then form arched structures flexibly linked to the SMP domain. [[cite:PUB00075878], [cite:PUB00148191], [cite:PUB00148192], [cite:PUB00148193], [cite:PUB00148197], [cite:PUB00148194], [cite:PUB00145852], [cite:PUB00148195], [cite:PUB00148196], [cite:PUB00093119], [cite:PUB00148190], [cite:PUB00087567], [cite:PUB00146909], [cite:PUB00146903], [cite:PUB00146904], [cite:PUB00146905], [cite:PUB00146906], [cite:PUB00060834], [cite:PUB00111794], [cite:PUB00146907], [cite:PUB00146908], [cite:PUB00092089]]
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Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.","URL":null,"raw_pages":"514-529.e20","medline_journal":"Cell","ISO_journal":"Cell","authors":["Sandhu J","Li S","Fairall L","Pfisterer SG","Gurnett JE","Xiao X","Weston TA","Vashi D","Ferrari A","Orozco JL","Hartman CL","Strugatsky D","Lee SD","He C","Hong C","Jiang H","Bentolila LA","Gatta AT","Levine TP","Ferng A","Lee R","Ford DA","Young SG","Ikonen E","Schwabe JWR","Tontonoz P."],"DOI_URL":null},"PUB00148191":{"PMID":27348751,"ISBN":null,"volume":"11","issue":"6","year":2016,"title":"Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction.","URL":null,"raw_pages":"e0158295","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Sclip A","Bacaj T","Giam LR","Sudhof TC."],"DOI_URL":null},"PUB00148190":{"PMID":24183667,"ISBN":null,"volume":"5","issue":"3","year":2013,"title":"Feedback regulation of 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lipid homeostasis by the extended synaptotagmins.","URL":null,"raw_pages":"504-15","medline_journal":"Nat Cell Biol","ISO_journal":"Nat Cell Biol","authors":["Saheki Y","Bian X","Schauder CM","Sawaki Y","Surma MA","Klose C","Pincet F","Reinisch KM","De Camilli P."],"DOI_URL":null},"PUB00060834":{"PMID":19690332,"ISBN":null,"volume":"2","issue":"84","year":2009,"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","URL":null,"raw_pages":"ra46","medline_journal":"Sci Signal","ISO_journal":"Sci Signal","authors":["Mayya V","Lundgren DH","Hwang SI","Rezaul K","Wu L","Eng JK","Rodionov V","Han DK."],"DOI_URL":"http://dx.doi.org/10.1126/scisignal.2000007"},"PUB00146904":{"PMID":24373768,"ISBN":null,"volume":"22","issue":"2","year":2014,"title":"Structure and Ca²⁺-binding properties of the tandem C₂ domains of 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