{"metadata":{"accession":"cd17205","entry_id":null,"type":"domain","go_terms":null,"source_database":"cdd","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in erythrocyte membrane protein band 4.1-like 5 (EPB41L5)","short":"FERM_F1_EPB41L5"},"description":[{"text":"<p>EPB41L5 is a mesenchymal-specific protein that is an integral component of the ARF6-based pathway. It is normally induced during epithelial-mesenchymal transition (EMT) by an EMT-related transcriptional factor, ZEB1, which drives ARF6-based invasion, metastasis and drug resistance. EPB41L5 also binds to paxillin to enhance integrin/paxillin association, and thus promotes focal adhesion dynamics. Moreover, EPB41L5 acts as a substrate for the E3 ubiquitin ligase Mind bomb 1 (Mib1), which is essential for activation of Notch signaling. EPB41L5 is a member of the band 4.1/Nbl4 (novel band 4.1-like protein 4) group of the FERM protein superfamily. It contains a FERM domain that is made up of three sub-domains, F1, F2, and F3. This family corresponds to the F1 sub-domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N). [[cite:PUB00073790], [cite:PUB00138788], [cite:PUB00138789], [cite:PUB00138790], [cite:PUB00138791], [cite:PUB00138792]]</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00138792":{"PMID":18794329,"ISBN":null,"volume":"182","issue":"6","year":2008,"title":"EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition.","URL":null,"raw_pages":"1217-30","medline_journal":"J Cell Biol","ISO_journal":"J Cell Biol","authors":["Hirano M","Hashimoto S","Yonemura S","Sabe H","Aizawa S."],"DOI_URL":null},"PUB00138788":{"PMID":28536193,"ISBN":null,"volume":"114","issue":"23","year":2017,"title":"The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier.","URL":null,"raw_pages":"E4621-E4630","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Schell C","Rogg M","Suhm M","Helmstadter M","Sellung D","Yasuda-Yamahara M","Kretz O","Kuttner V","Suleiman H","Kollipara L","Zahedi RP","Sickmann A","Eimer S","Shaw AS","Kramer-Zucker A","Hirano-Kobayashi M","Abe T","Aizawa S","Grahammer F","Hartleben B","Dengjel J","Huber TB."],"DOI_URL":null},"PUB00138790":{"PMID":27617643,"ISBN":null,"volume":"5","issue":"9","year":2016,"title":"ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance.","URL":null,"raw_pages":"e259","medline_journal":"Oncogenesis","ISO_journal":"Oncogenesis","authors":["Hashimoto A","Hashimoto S","Sugino H","Yoshikawa A","Onodera Y","Handa H","Oikawa T","Sabe H."],"DOI_URL":null},"PUB00138791":{"PMID":27510968,"ISBN":null,"volume":"143","issue":"17","year":2016,"title":"Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons.","URL":null,"raw_pages":"3085-96","medline_journal":"Development","ISO_journal":"Development","authors":["Matsuda M","Rand K","Palardy G","Shimizu N","Ikeda H","Dalle Nogare D","Itoh M","Chitnis AB."],"DOI_URL":null},"PUB00138789":{"PMID":27754741,"ISBN":null,"volume":"9","issue":"5","year":2018,"title":"Arf6 and its ZEB1-EPB41L5 mesenchymal axis are required for both mesenchymal- and amoeboid-type invasion of cancer cells.","URL":null,"raw_pages":"420-426","medline_journal":"Small GTPases","ISO_journal":"Small GTPases","authors":["Handa H","Hashimoto A","Hashimoto S","Sabe H."],"DOI_URL":null},"PUB00073790":{"PMID":17920587,"ISBN":null,"volume":"313","issue":"19","year":2007,"title":"FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex.","URL":null,"raw_pages":"3959-70","medline_journal":"Exp Cell Res","ISO_journal":"Exp. Cell Res.","authors":["Gosens I","Sessa A","den Hollander AI","Letteboer SJ","Belloni V","Arends ML","Le Bivic A","Cremers FP","Broccoli V","Roepman R."],"DOI_URL":"http://dx.doi.org/10.1016/j.yexcr.2007.08.025"}},"set_info":{"accession":"cl28922","name":"Ubl1_cv_Nsp3_N-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":764,"pathways":0,"proteins":764,"proteomes":224,"sets":1,"structural_models":{"alphafold":670,"bfvd":0},"structures":0,"taxa":845},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}