{"metadata":{"accession":"cd12433","entry_id":null,"type":"domain","go_terms":null,"source_database":"cdd","member_databases":null,"integrated":"IPR034260","hierarchy":null,"name":{"name":"RNA recognition motif (RRM) found in yeast mitochondrial escape protein 2 (Yme2p) and similar proteins","short":"RRM_Yme2p_like"},"description":[{"text":"<p>This subfamily corresponds to the RRM of Yme2p, also termed protein RNA12, an inner mitochondrial membrane protein that plays a critical role in mitochondrial DNA transactions. It may serve as a mediator of nucleoid structure and number in mitochondria of the yeast Saccharomyces cerevisiae. Yme2p contains an exonuclease domain, an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a C-terminal domain.  [[cite:PUB00044464], [cite:PUB00044894], [cite:PUB00129581], [cite:PUB00044895], [cite:PUB00079469], [cite:PUB00079470]]</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00044894":{"PMID":8649384,"ISBN":null,"volume":"16","issue":"6","year":1996,"title":"Inactivation of YME2/RNA12, which encodes an integral inner mitochondrial membrane protein, causes increased escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae.","URL":null,"raw_pages":"2764-71","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Hanekamp T","Thorsness PE."],"DOI_URL":null},"PUB00044895":{"PMID":16850347,"ISBN":null,"volume":"50","issue":"3","year":2006,"title":"Yme2p is a mediator of nucleoid structure and number in mitochondria of the yeast Saccharomyces cerevisiae.","URL":null,"raw_pages":"173-82","medline_journal":"Curr Genet","ISO_journal":"Curr. Genet.","authors":["Park S","Hanekamp T","Thorsness MK","Thorsness PE."],"DOI_URL":"http://dx.doi.org/10.1007/s00294-006-0087-9"},"PUB00044464":{"PMID":1557037,"ISBN":null,"volume":"232","issue":"2","year":1992,"title":"rna12+, a gene of Saccharomyces cerevisiae involved in pre-rRNA maturation. Characterization of a temperature-sensitive mutant, cloning and sequencing of the gene.","URL":null,"raw_pages":"304-12","medline_journal":"Mol Gen Genet","ISO_journal":"Mol. Gen. Genet.","authors":["Liang S","Alksne L","Warner JR","Lacroute F."],"DOI_URL":null},"PUB00079470":{"PMID":22278943,"ISBN":null,"volume":"3","issue":"2","year":2012,"title":"Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems.","URL":null,"raw_pages":"229-46","medline_journal":"Wiley Interdiscip Rev RNA","ISO_journal":"Wiley Interdiscip Rev RNA","authors":["Muto Y","Yokoyama S."],"DOI_URL":"http://dx.doi.org/10.1002/wrna.1107"},"PUB00079469":{"PMID":22516180,"ISBN":null,"volume":"22","issue":"3","year":2012,"title":"Dynamics in multi-domain protein recognition of RNA.","URL":null,"raw_pages":"287-96","medline_journal":"Curr Opin Struct Biol","ISO_journal":"Curr. Opin. Struct. Biol.","authors":["Mackereth CD","Sattler M."],"DOI_URL":"http://dx.doi.org/10.1016/j.sbi.2012.03.013"},"PUB00129581":{"PMID":11737636,"ISBN":null,"volume":"42","issue":"4","year":2001,"title":"The ZbYME2 gene from the food spoilage yeast Zygosaccharomyces bailii confers not only YME2 functions in Saccharomyces cerevisiae, but also the capacity for catabolism of sorbate and benzoate, two major weak organic acid preservatives.","URL":null,"raw_pages":"919-30","medline_journal":"Mol Microbiol","ISO_journal":"Mol Microbiol","authors":["Mollapour M","Piper PW."],"DOI_URL":null}},"set_info":{"accession":"cl17169","name":"RRM_SF"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":964,"pathways":0,"proteins":963,"proteomes":773,"sets":1,"structural_models":{"alphafold":826,"bfvd":0},"structures":0,"taxa":1702},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}