{"metadata":{"accession":"cd03693","entry_id":null,"type":"domain","go_terms":null,"source_database":"cdd","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"Domain II of elongation factor 1-alpha","short":"EF1_alpha_II"},"description":[{"text":"<p>This family represents domain II of elongation factor 1-alpha (EF-1A) that is found in archaea and all eukaryotic lineages. EF-1A is very abundant in the cytosol, where it is involved in the GTP-dependent binding of aminoacyl-tRNAs to the A site of the ribosomes in the second step of translation from mRNAs to proteins. Both domain II of EF-1A and domain IV of IF2/eIF5B have been implicated in recognition of the 3'-ends of tRNA. More than 61% of eukaryotic elongation factor 1A (eEF-1A) in cells is estimated to be associated with actin cytoskeleton. The binding of eEF-1A to actin is a noncanonical function that may link two distinct cellular processes, cytoskeleton organization and gene expression. [[cite:PUB00115982], [cite:PUB00115983], [cite:PUB00115094], [cite:PUB00080181], [cite:PUB00033952], [cite:PUB00027704], [cite:PUB00033961], [cite:PUB00079814], [cite:PUB00007398]]</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00033961":{"PMID":12102560,"ISBN":null,"volume":"71","issue":null,"year":2002,"title":"Mechanisms of EF-Tu, a pioneer GTPase.","URL":null,"raw_pages":"513-51","medline_journal":"Prog Nucleic Acid Res Mol Biol","ISO_journal":"Prog. Nucleic Acid Res. Mol. 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