{"metadata":{"accession":"IPR053618","entry_id":null,"type":"family","go_terms":null,"source_database":"interpro","member_databases":{"ncbifam":{"NF041140":"tRNA N1-methyltransferase"}},"integrated":null,"hierarchy":{"accession":"IPR053618","name":"tRNA N1-methyltransferase","type":"Family","children":[]},"name":{"name":"tRNA N1-methyltransferase","short":"tRNA_N1-methyltransferase"},"description":[{"text":"<p>This family of proteins includes enzymes that function as tRNA methyltransferases. Members of this family are responsible for the methylation of guanine(9) and adenine(9) at the N1 position in tRNA molecules. They utilize S-adenosyl-L-methionine as the methyl donor for this modification. The methylation of nucleotides at this position is crucial for the stability and function of tRNA, impacting its overall structure and interaction with other molecules during protein synthesis. The enzymatic activity of these proteins is essential for the proper decoding of genetic information and the fidelity of protein translation.</p>","llm":true,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075405":{"PMID":20525789,"ISBN":null,"volume":"38","issue":"19","year":2010,"title":"New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA.","URL":null,"raw_pages":"6533-43","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Kempenaers M","Roovers M","Oudjama Y","Tkaczuk KL","Bujnicki JM","Droogmans L."],"DOI_URL":"http://dx.doi.org/10.1093/nar/gkq451"}},"set_info":null,"overlaps_with":[{"accession":"IPR038459","name":"tRNA methyltransferase TRM10-type domain superfamily","type":"homologous_superfamily"}],"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":41,"pathways":0,"proteins":41,"proteomes":35,"sets":0,"structural_models":{"alphafold":40,"bfvd":0},"structures":1,"taxa":60},"entry_annotations":{},"cross_references":{},"is_llm":true,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6ems","name":"Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis."}}}