{"metadata":{"accession":"IPR049651","entry_id":null,"type":"family","go_terms":null,"source_database":"interpro","member_databases":{"ncbifam":{"NF041673":"acetate metabolism transcriptional regulator RamA"}},"integrated":null,"hierarchy":{"accession":"IPR049651","name":"HTH-type transcriptional activator RamA-like","type":"Family","children":[]},"name":{"name":"HTH-type transcriptional activator RamA-like","short":"HTH-type_RamA-like"},"description":[{"text":"<p>This entry represents a group of proteins from actinomycetes,  including HTH-type transcriptional activator RamA from Corynebacterium glutamicum ([swissprot:Q8NML3]), a master regulator of acetate metabolism. RamA positively controls the expression of acnA, aceA, aceB, ack, pta and ramB genes in the presence of acetate [[cite:PUB00152919], [cite:PUB00153071], [cite:PUB00152920]] and a positive regulator of rpf2 gene expression during growth on glucose as the sole carbon source [[cite:PUB00152921]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00152919":{"PMID":16547043,"ISBN":null,"volume":"188","issue":"7","year":2006,"title":"Identification of RamA, a novel LuxR-type transcriptional regulator of genes involved in acetate metabolism of Corynebacterium glutamicum.","URL":null,"raw_pages":"2554-67","medline_journal":"J Bacteriol","ISO_journal":"J Bacteriol","authors":["Cramer A","Gerstmeir R","Schaffer S","Bott M","Eikmanns BJ."],"DOI_URL":"https://doi.org/10.1128/JB.188.7.2554-2567.2006"},"PUB00152920":{"PMID":19095019,"ISBN":null,"volume":"140","issue":"1-2","year":2009,"title":"Complex expression control of the Corynebacterium glutamicum aconitase gene: identification of RamA as a third transcriptional regulator besides AcnR and RipA.","URL":null,"raw_pages":"92-8","medline_journal":"J Biotechnol","ISO_journal":"J Biotechnol","authors":["Emer D","Krug A","Eikmanns BJ","Bott M."],"DOI_URL":"https://doi.org/10.1016/j.jbiotec.2008.11.003"},"PUB00152921":{"PMID":18355281,"ISBN":null,"volume":"281","issue":"2","year":2008,"title":"Triple transcriptional control of the resuscitation promoting factor 2 (rpf2) gene of Corynebacterium glutamicum by the regulators of acetate metabolism RamA and RamB and the cAMP-dependent regulator GlxR.","URL":null,"raw_pages":"190-7","medline_journal":"FEMS Microbiol Lett","ISO_journal":"FEMS Microbiol Lett","authors":["Jungwirth B","Emer D","Brune I","Hansmeier N","Puhler A","Eikmanns BJ","Tauch A."],"DOI_URL":"https://doi.org/10.1111/j.1574-6968.2008.01098.x"},"PUB00153071":{"PMID":17114251,"ISBN":null,"volume":"189","issue":"3","year":2007,"title":"RamB, the transcriptional regulator of acetate metabolism in Corynebacterium glutamicum, is subject to regulation by RamA and RamB.","URL":null,"raw_pages":"1145-9","medline_journal":"J Bacteriol","ISO_journal":"J Bacteriol","authors":["Cramer A","Auchter M","Frunzke J","Bott M","Eikmanns BJ."],"DOI_URL":"https://doi.org/10.1128/JB.01061-06"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":204,"pathways":0,"proteins":204,"proteomes":153,"sets":0,"structural_models":{"alphafold":163,"bfvd":0},"structures":0,"taxa":215},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}