{"metadata":{"accession":"IPR032355","entry_id":null,"type":"domain","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}}],"source_database":"interpro","member_databases":{"profile":{"PS51983":"CUT repeat-like (CUTL) domain profile"},"pfam":{"PF16557":"CUT1-like DNA-binding domain of SATB"}},"integrated":null,"hierarchy":{"accession":"IPR032355","name":"SATB, CUT1-like DNA-binding domain","type":"Domain","children":[]},"name":{"name":"SATB, CUT1-like DNA-binding domain","short":"CUTL"},"description":[{"text":"<p>The CUTL domain is part of the N-terminal region of SATB proteins, special AT-rich sequence-binding proteins that are global chromatin organisers and gene expression regulators essential for T-cell development and breast cancer tumour growth and metastasis. This domain carries a DNA-binding region [[cite:PUB00076270], [cite:PUB00097436]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00076270":{"PMID":22241778,"ISBN":null,"volume":"40","issue":"9","year":2012,"title":"The structural basis for the oligomerization of the N-terminal domain of SATB1.","URL":null,"raw_pages":"4193-202","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Wang Z","Yang X","Chu X","Zhang J","Zhou H","Shen Y","Long J."],"DOI_URL":"http://dx.doi.org/10.1093/nar/gkr1284"},"PUB00097436":{"PMID":25124042,"ISBN":null,"volume":"289","issue":"40","year":2014,"title":"Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism.","URL":null,"raw_pages":"27376-85","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Wang Z","Yang X","Guo S","Yang Y","Su XC","Shen Y","Long J."],"DOI_URL":null}},"set_info":null,"overlaps_with":[{"accession":"IPR038216","name":"SATB, CUTL domain superfamily","type":"homologous_superfamily"}],"counters":{"subfamilies":0,"domain_architectures":34,"interactions":0,"matches":2910,"pathways":5,"proteins":2909,"proteomes":769,"sets":0,"structural_models":{"alphafold":2623,"bfvd":0},"structures":3,"taxa":2468},"entry_annotations":{"alignment:seed":3,"alignment:full":2152},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3nzl","name":"Crystal Structure of the N-terminal domain of DNA-binding protein SATB1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4435B"}}}