Myelin regulatory factor (Myrf) is a transcription regulator required in vertebrates for expression of central nervous system (CNS) myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and CNS myelination [[cite:PUB00057918]]. It is also required for the maintenance of expression of myelin genes and the mature oligodendrocytes identity in the adult CNS [[cite:PUB00062316], [cite:PUB00095183]]. A Caenorhabditis elegans orthologue, pqn-47, may function as a regulator of molting [[cite:PUB00062040]], while a Dictyostelium orthologue has been described to regulate prestalk differentiation [[cite:PUB00062039]].
","llm":false,"checked":false,"updated":false},{"text":"This domain is found towards the C terminus of myelin regulatory factor (Myrf) and corresponds to the Intramolecular Chaperone Auto-processing (ICA) domain. It forms a homo-trimer and carries out the auto-cleavage of Myrf releasing the N-terminal homo-trimer from the ER membrane. This allows its entry to the nucleus to function as a homo-trimer transcription factor [[cite:PUB00095183]].
","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00062040":{"PMID":21989027,"ISBN":null,"volume":"360","issue":"2","year":2011,"title":"Regulation of the C. elegans molt by pqn-47.","URL":null,"raw_pages":"297-309","medline_journal":"Dev Biol","ISO_journal":"Dev. Biol.","authors":["Russel S","Frand AR","Ruvkun G."],"DOI_URL":"http://dx.doi.org/10.1016/j.ydbio.2011.09.025"},"PUB00062039":{"PMID":22811266,"ISBN":null,"volume":"56","issue":"5","year":2012,"title":"An orthologue of the Myelin-gene Regulatory Transcription Factor regulates Dictyostelium prestalk differentiation.","URL":null,"raw_pages":"325-32","medline_journal":"Int J Dev Biol","ISO_journal":"Int. J. Dev. Biol.","authors":["Senoo H","Wang HY","Araki T","Williams JG","Fukuzawa M."],"DOI_URL":null},"PUB00062316":{"PMID":22956843,"ISBN":null,"volume":"32","issue":"36","year":2012,"title":"Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS.","URL":null,"raw_pages":"12528-42","medline_journal":"J Neurosci","ISO_journal":"J. Neurosci.","authors":["Koenning M","Jackson S","Hay CM","Faux C","Kilpatrick TJ","Willingham M","Emery B."],"DOI_URL":"http://dx.doi.org/10.1523/JNEUROSCI.1069-12.2012"},"PUB00057918":{"PMID":19596243,"ISBN":null,"volume":"138","issue":"1","year":2009,"title":"Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination.","URL":null,"raw_pages":"172-85","medline_journal":"Cell","ISO_journal":"Cell","authors":["Emery B","Agalliu D","Cahoy JD","Watkins TA","Dugas JC","Mulinyawe SB","Ibrahim A","Ligon KL","Rowitch DH","Barres BA."],"DOI_URL":"http://dx.doi.org/10.1016/j.cell.2009.04.031"},"PUB00095183":{"PMID":31964908,"ISBN":null,"volume":"10","issue":"1","year":2020,"title":"Functional mechanism and pathogenic potential of MYRF ICA domain mutations implicated in birth defects.","URL":null,"raw_pages":"814","medline_journal":"Sci Rep","ISO_journal":"Sci Rep","authors":["An H","Fan C","Sharif M","Kim D","Poitelon Y","Park Y."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":34,"interactions":0,"matches":2852,"pathways":0,"proteins":2846,"proteomes":1098,"sets":0,"structural_models":{"alphafold":2349,"bfvd":0},"structures":1,"taxa":3704},"entry_annotations":{"alignment:seed":8,"alignment:full":1897},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}