{"metadata":{"accession":"IPR025655","entry_id":null,"type":"family","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016560","name":"protein import into peroxisome matrix, docking","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005778","name":"peroxisomal membrane","category":{"code":"C","name":"cellular_component"}}],"source_database":"interpro","member_databases":{"panther":{"PTHR23058":"PEROXISOMAL MEMBRANE PROTEIN PEX14"}},"integrated":null,"hierarchy":{"accession":"IPR025655","name":"Peroxisomal membrane protein 14","type":"Family","children":[]},"name":{"name":"Peroxisomal membrane protein 14","short":"PEX14"},"description":[{"text":"<p>Peroxisomal membrane protein PEX14, or peroxin-14, is a core component of the peroxisomal translocation machinery or importomer [[cite:PUB00055948], [cite:PUB00050069]]. PEX14 is involved in the docking of PEX5-bound protein onto the peroxisomal membrane, and it may be involved in the translocation step into the peroxisome matrix [[cite:PUB00068179]]. In addition to its role in protein docking, a role in transcriptional regulation has also been suggested for PEX14 [[cite:PUB00057430]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00055948":{"PMID":10704444,"ISBN":null,"volume":"148","issue":"5","year":2000,"title":"PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.","URL":null,"raw_pages":"931-44","medline_journal":"J Cell Biol","ISO_journal":"J. Cell Biol.","authors":["Sacksteder KA","Jones JM","South ST","Li X","Liu Y","Gould SJ."],"DOI_URL":"http://dx.doi.org/10.1083/jcb.148.5.931"},"PUB00050069":{"PMID":19197237,"ISBN":null,"volume":"28","issue":"6","year":2009,"title":"Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.","URL":null,"raw_pages":"745-54","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Neufeld C","Filipp FV","Simon B","Neuhaus A","Schuller N","David C","Kooshapur H","Madl T","Erdmann R","Schliebs W","Wilmanns M","Sattler M."],"DOI_URL":"http://dx.doi.org/10.1038/emboj.2009.7"},"PUB00057430":{"PMID":11863372,"ISBN":null,"volume":"79","issue":"3","year":2002,"title":"NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor.","URL":null,"raw_pages":"423-31","medline_journal":"Genomics","ISO_journal":"Genomics","authors":["Gavva NR","Wen SC","Daftari P","Moniwa M","Yang WM","Yang-Feng LP","Seto E","Davie JR","Shen CK."],"DOI_URL":"http://dx.doi.org/10.1006/geno.2002.6714"},"PUB00068179":{"PMID":17046076,"ISBN":null,"volume":"1763","issue":"12","year":2006,"title":"Pex14p, more than just a docking protein.","URL":null,"raw_pages":"1574-84","medline_journal":"Biochim Biophys Acta","ISO_journal":"Biochim. Biophys. Acta","authors":["Azevedo JE","Schliebs W."],"DOI_URL":"http://dx.doi.org/10.1016/j.bbamcr.2006.09.002"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":6050,"pathways":18,"proteins":6050,"proteomes":2987,"sets":0,"structural_models":{"alphafold":5410,"bfvd":0},"structures":19,"taxa":8431},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5aon","name":"Crystal structure of the conserved N-terminal domain of Pex14 from Trypanosoma brucei"}}}