{"metadata":{"accession":"IPR020162","entry_id":null,"type":"family","go_terms":[{"identifier":"GO:0021549","name":"cerebellum development","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0030182","name":"neuron differentiation","category":{"code":"P","name":"biological_process"}}],"source_database":"interpro","member_databases":{"pfam":{"PF15677":"Cell cycle exit and neuronal differentiation protein 1"},"panther":{"PTHR36683":"CELL CYCLE EXIT AND NEURONAL DIFFERENTIATION PROTEIN 1"}},"integrated":null,"hierarchy":{"accession":"IPR020162","name":"Cell cycle exit/neuronal differentiation protein 1","type":"Family","children":[]},"name":{"name":"Cell cycle exit/neuronal differentiation protein 1","short":"Cend1"},"description":[{"text":"<p>Cell cycle exit and neuronal differentiation protein 1 (Cend1 or BM88) is a homodimer of 140 amino acids. It has a putative transmembrane domain at the C terminus. The mRNA of this protein is expressed only in neural tissues, where it is restricted to neurons. It is involved in neuroblastoma cell differentiation [[cite:PUB00045934], [cite:PUB00075749]], neuronal differentiation [[cite:PUB00075748]], and development of the cerebellum [[cite:PUB00075747]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00045934":{"PMID":7775480,"ISBN":null,"volume":"270","issue":"23","year":1995,"title":"The BM88 antigen, a novel neuron-specific molecule, enhances the differentiation of mouse neuroblastoma cells.","URL":null,"raw_pages":"14201-8","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Mamalaki A","Boutou E","Hurel C","Patsavoudi E","Tzartos S","Matsas R."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.270.23.14201"},"PUB00075747":{"PMID":20153830,"ISBN":null,"volume":"44","issue":"1","year":2010,"title":"Impaired cerebellar development and deficits in motor coordination in mice lacking the neuronal protein BM88/Cend1.","URL":null,"raw_pages":"15-29","medline_journal":"Mol Cell Neurosci","ISO_journal":"Mol. Cell. Neurosci.","authors":["Sergaki MC","Guillemot F","Matsas R."],"DOI_URL":"http://dx.doi.org/10.1016/j.mcn.2010.01.011"},"PUB00075748":{"PMID":23658157,"ISBN":null,"volume":"33","issue":"19","year":2013,"title":"Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.","URL":null,"raw_pages":"8172-84","medline_journal":"J Neurosci","ISO_journal":"J. Neurosci.","authors":["Weng L","Lin YF","Li AL","Wang CE","Yan S","Sun M","Gaertig MA","Mitha N","Kosaka J","Wakabayashi T","Xu X","Tang B","Li S","Li XJ."],"DOI_URL":"http://dx.doi.org/10.1523/JNEUROSCI.0119-13.2013"},"PUB00075749":{"PMID":24312406,"ISBN":null,"volume":"8","issue":"11","year":2013,"title":"Functional Interactions between BM88/Cend1, Ran-binding protein M and Dyrk1B kinase affect cyclin D1 levels and cell cycle progression/exit in mouse neuroblastoma cells.","URL":null,"raw_pages":"e82172","medline_journal":"PLoS One","ISO_journal":"PLoS ONE","authors":["Tsioras K","Papastefanaki F","Politis PK","Matsas R","Gaitanou M."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pone.0082172"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":619,"pathways":0,"proteins":618,"proteomes":572,"sets":0,"structural_models":{"alphafold":586,"bfvd":0},"structures":0,"taxa":1802},"entry_annotations":{"alignment:seed":7,"alignment:full":529},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}