{"metadata":{"accession":"IPR019595","entry_id":null,"type":"domain","go_terms":null,"source_database":"interpro","member_databases":{"pfam":{"PF10615":"Domain of unknown function (DUF2470)"}},"integrated":null,"hierarchy":{"accession":"IPR019595","name":"Domain of unknown function DUF2470","type":"Domain","children":[]},"name":{"name":"Domain of unknown function DUF2470","short":"DUF2470"},"description":[{"text":"<p>This entry represents an uncharacterised domain that can be found in a group of putative haem-iron utilisation proteins, such as HugZ from H. pylori and non-canonical heme oxygenase HOZ form Arabidopsis. HOZ is a dimeric β-barrel protein that binds to heme and catalyses its degradation to produce biliverdin [[cite:PUB00155388]]. This domain can also be found in C-terminal of the glutamyl-tRNA reductase-binding (GluTRBP) protein from Arabidopsis [[cite:PUB00075508]]. GluTRBP is involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis [[cite:PUB00075509]]. GluTRBP is necessary for efficient photosynthetic electron transport in chloroplasts [[cite:PUB00075510]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075508":{"PMID":24753615,"ISBN":null,"volume":"111","issue":"18","year":2014,"title":"Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein.","URL":null,"raw_pages":"6630-5","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Zhao A","Fang Y","Chen X","Zhao S","Dong W","Lin Y","Gong W","Liu L."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.1400166111"},"PUB00075509":{"PMID":22180625,"ISBN":null,"volume":"23","issue":"12","year":2011,"title":"An Arabidopsis GluTR binding protein mediates spatial separation of 5-aminolevulinic acid synthesis in chloroplasts.","URL":null,"raw_pages":"4476-91","medline_journal":"Plant Cell","ISO_journal":"Plant Cell","authors":["Czarnecki O","Hedtke B","Melzer M","Rothbart M","Richter A","Schroter Y","Pfannschmidt T","Grimm B."],"DOI_URL":"http://dx.doi.org/10.1105/tpc.111.086421"},"PUB00075510":{"PMID":20657737,"ISBN":null,"volume":"5","issue":"7","year":2010,"title":"Arabidopsis thaliana PGR7 encodes a conserved chloroplast protein that is necessary for efficient photosynthetic electron transport.","URL":null,"raw_pages":"e11688","medline_journal":"PLoS One","ISO_journal":"PLoS ONE","authors":["Jung HS","Okegawa Y","Shih PM","Kellogg E","Abdel-Ghany SE","Pilon M","Sjolander K","Shikanai T","Niyogi KK."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pone.0011688"},"PUB00155388":{"PMID":33284325,"ISBN":null,"volume":null,"issue":null,"year":2020,"title":"The Arabidopsis locus AT3G03890 encodes a dimeric β-barrel protein implicated in heme degradation.","URL":null,"raw_pages":"BCJ20200712","medline_journal":"Biochem J","ISO_journal":"Biochem J","authors":["Wang J","Guo Q","Li X","Wang X","Liu L."],"DOI_URL":"https://doi.org/10.1042/BCJ20200712"}},"set_info":null,"overlaps_with":[{"accession":"IPR037119","name":"Haem oxygenase HugZ-like superfamily","type":"homologous_superfamily"}],"counters":{"subfamilies":0,"domain_architectures":84,"interactions":0,"matches":9418,"pathways":0,"proteins":9410,"proteomes":5475,"sets":0,"structural_models":{"alphafold":7106,"bfvd":0},"structures":16,"taxa":9973},"entry_annotations":{"alignment:seed":166,"alignment:full":4274},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8zxq","name":"Crystal structure of Ssr1698 in complex with heme b"}}}