{"metadata":{"accession":"IPR008422","entry_id":null,"type":"domain","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}}],"source_database":"interpro","member_databases":{"pfam":{"PF05920":"Homeobox KN domain"}},"integrated":null,"hierarchy":{"accession":"IPR001356","name":"Homeodomain","type":"Domain","children":[{"accession":"IPR008422","name":"KN homeodomain","type":"Domain","children":[]},{"accession":"IPR020479","name":"Homeodomain, metazoa","type":"Domain","children":[{"accession":"IPR000747","name":"Homeodomain engrailed","type":"Domain","children":[]}]},{"accession":"IPR056560","name":"Nodulin homeobox, homeobox-like domain","type":"Domain","children":[]},{"accession":"IPR058631","name":"Teashirt homolog 1-3-like, homeodomain","type":"Domain","children":[]}]},"name":{"name":"KN homeodomain","short":"KN_HD"},"description":[{"text":"<p>This entry represents a homeodomain (HD) present in transcription factors conserved from fungi to human and plants [[cite:PUB00053798]]. Genes encoding these proteins were first identified as TALE homeobox proteins in eukaryotes, (including KNOX and MEIS genes) [[cite:PUB00053798], [cite:PUB00075494], [cite:PUB00020003]]. They have been classified [[cite:PUB00075495], [cite:PUB00075496], [cite:PUB00075497]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00053798":{"PMID":17429685,"ISBN":null,"volume":"217","issue":"5","year":2007,"title":"Expression patterns of class I KNOX and YABBY genes in Ruscus aculeatus (Asparagaceae) with implications for phylloclade homology.","URL":null,"raw_pages":"363-72","medline_journal":"Dev Genes Evol","ISO_journal":"Dev. Genes Evol.","authors":["Hirayama Y","Yamada T","Oya Y","Ito M","Kato M","Imaichi R."],"DOI_URL":"http://dx.doi.org/10.1007/s00427-007-0149-0"},"PUB00075494":{"PMID":8537382,"ISBN":null,"volume":"270","issue":"52","year":1995,"title":"A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif.","URL":null,"raw_pages":"31178-88","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Bertolino E","Reimund B","Wildt-Perinic D","Clerc RG."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.270.52.31178"},"PUB00020003":{"PMID":9336443,"ISBN":null,"volume":"25","issue":"21","year":1997,"title":"Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals.","URL":null,"raw_pages":"4173-80","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Burglin TR."],"DOI_URL":"http://dx.doi.org/10.1093/nar/25.21.4173"},"PUB00075495":{"PMID":17665086,"ISBN":null,"volume":"65","issue":"2","year":2007,"title":"Comprehensive analysis of animal TALE homeobox genes: new conserved motifs and cases of accelerated evolution.","URL":null,"raw_pages":"137-53","medline_journal":"J Mol Evol","ISO_journal":"J. Mol. Evol.","authors":["Mukherjee K","Burglin TR."],"DOI_URL":"http://dx.doi.org/10.1007/s00239-006-0023-0"},"PUB00075496":{"PMID":19734295,"ISBN":null,"volume":"26","issue":"12","year":2009,"title":"A comprehensive classification and evolutionary analysis of plant homeobox genes.","URL":null,"raw_pages":"2775-94","medline_journal":"Mol Biol Evol","ISO_journal":"Mol. Biol. Evol.","authors":["Mukherjee K","Brocchieri L","Burglin TR."],"DOI_URL":"http://dx.doi.org/10.1093/molbev/msp201"},"PUB00075497":{"PMID":21557080,"ISBN":null,"volume":"52","issue":null,"year":2011,"title":"Homeodomain subtypes and functional diversity.","URL":null,"raw_pages":"95-122","medline_journal":"Subcell Biochem","ISO_journal":"Subcell. Biochem.","authors":["Burglin TR."],"DOI_URL":"http://dx.doi.org/10.1007/978-90-481-9069-0_5"}},"set_info":null,"overlaps_with":[{"accession":"IPR009057","name":"Homedomain-like superfamily","type":"homologous_superfamily"}],"counters":{"subfamilies":0,"domain_architectures":400,"interactions":0,"matches":50878,"pathways":11,"proteins":50654,"proteomes":3226,"sets":0,"structural_models":{"alphafold":45470,"bfvd":3},"structures":28,"taxa":9865},"entry_annotations":{"alignment:seed":58,"alignment:full":32239},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4xrm","name":"homodimer of TALE type homeobox transcription factor MEIS1 complexes with specific DNA"}}}